Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice
TL;DR: Administration of pomegranate extract for 2 weeks to ovariectomized mice prevented the loss of uterus weight and shortened the immobility time compared with 5% glucose-dosed mice (control), and changes suggest that the pome granate extract inhibits ovariectomy-stimulated bone turnover.
Journal ArticleDOI
The depressive-like behaviors are correlated with decreased phosphorylation of mitogen-activated protein kinases in rat brain following chronic forced swim stress.
TL;DR: Chronic forced swim stress was a good animal model of depression, and it induced depressive-like behavior and decreased P-Erk2 in the hippocampus and prefrontal cortex in rats.
Journal Article
Interaction Between the Forced Swimming Test and Fluoxetine Treatment on Extracellular 5-Hydroxytryptamine and 5-Hydroxyindoleacetic Acid in the Rat
Lynn G. Kirby,Irwin Lucki +1 more
TL;DR: In vivo microdialysis examined extracellular levels of 5-hydroxytryptamine and 5-HIAA in the striatum and the lateral septum during the FST, a behavioral test conducted in rats that is commonly used to predict the effect of antidepressant drugs, to show that fluoxetine treatment increased swimming behavior and decreased immobility during the test swim.
Journal ArticleDOI
Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats.
TL;DR: The present study found that ODQ significantly decreased the immobility time in the FST compared to the control and suggested that the NO-sGC-cGMP pathway may play an important role in the mediation of the behavioural effect in theFST without influence on motor activity.
Journal ArticleDOI
Chronic agomelatine treatment corrects behavioral, cellular, and biochemical abnormalities induced by prenatal stress in rats.
Sara Morley-Fletcher,Jérôme Mairesse,Amélie Soumier,Mounira Banasr,Francesca Fagioli,Cecilia Gabriel,Elisabeth Mocaer,Annie Daszuta,Bruce S. McEwen,Ferdinando Nicoletti,Stefania Maccari +10 more
TL;DR: These data indicate that agomelatine did not act on individual symptoms but corrected all aspects of the pathological epigenetic programming triggered by PRS, and suggest that the drug impacts mechanisms that lie at the core of anxious/depressive disorders.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
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The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more