Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Exposure to nicotine and ethanol in adolescent mice: Effects on depressive-like behavior during exposure and withdrawal
Anderson Ribeiro-Carvalho,Carla S. Lima,André L. Nunes-Freitas,Cláudio C. Filgueiras,Alex C. Manhães,Yael Abreu-Villaça +5 more
TL;DR: Adolescent nicotine, ethanol and nicotine+ethanol combined exposures during adolescence thus elicit gender-selective effects both during exposure and withdrawal that may contribute to the increased prevalence of depression among drug users.
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Effect of Chronic Administration of Antidepressants on Duration of Immobility in Rats Forced to Swim
TL;DR: The present results suggest that the chronic administration of drugs to rats in a forced swimming test can clarify the characteristics of the psychotropic drugs.
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Involvement of prefrontal dopamine neurones in behavioural blockade induced by controllable vs uncontrollable negative events in rats.
Sophie Ravard,Pascale Carnoy,Denis Hervé,Jean-Pol Tassin,Marie-Hélène Thiébot,Philippe Soubrie +5 more
TL;DR: The present findings suggest that an increased tendency to perseverate could be the main behavioural feature associated with DA lesion in the prefrontal cortex, and suggest that controllable and acute aversive situations may be modulated by DA neurones in the cortex.
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Characterization of motor, depressive-like and neurochemical alterations induced by a short-term rotenone administration
Lívia H. Morais,Marcelo M.S. Lima,Bruno Jacson Martynhak,Ronise M. Santiago,Tatiane T. Takahashi,Deborah Ariza,Janaína K. Barbiero,Roberto Andreatini,Maria A.B.F. Vital +8 more
TL;DR: Data suggest important participations of serotonin and noradrenaline in depressive-like behaviors induced by rotenone suggest an improvement regarding the existing rotenonemodels of PD.
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Motor and behavioral changes in rats with adenine-induced chronic renal failure: influence of acacia gum treatment.
TL;DR: Adenine-induced CRF caused motor and behavioral alterations, and these were significantly mitigated by administration of AG, which has been previously shown to ameliorate the severity of CRF in humans and rats.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
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The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more