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Journal ArticleDOI

Behavioural despair in rats: a new model sensitive to antidepressant treatments.

Roger D. Porsolt, +3 more
- 15 Feb 1978 - 
- Vol. 47, Iss: 4, pp 379-391
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
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This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.

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Journal ArticleDOI

Distribution of norepinephrine, epinephrine, dopamine, serotonin, 3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindole-3-acetic acid in dog brain.

TL;DR: Using the ratios 5-hydroxyindole-3-acetic acid/serotonin and homovanillic acid/dopamine as indicators of serotonin and dopamine turnover and utilization, both putative transmitters were found to be generally more highly utilized in areas of lower concentration, especially in brain stem and cortex.
Journal ArticleDOI

Increased extracellular serotonin level in rat hippocampus induced by chronic citalopram is augmented by subchronic lithium: neurochemical and behavioural studies in the rat

TL;DR: The present results support the assumption that increases in hippocampal 5-HT neurotransmission may be important in the augmentatory effect of lithium.
Journal ArticleDOI

Inhibitory effects of an orexin-2 receptor antagonist on orexin A- and stress-induced ACTH responses in conscious rats.

TL;DR: Results suggest that swimming stress facilitates ACTH release, at least in part via activation of OX-2R, and increases in ACTH levels with orexin A or swimming stress were attenuated with prior administration of an OX -2R antagonist.
Journal ArticleDOI

Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depression.

TL;DR: Examination of the interaction between social stress and the resulting depressive behaviors in NET-KO mice suggests that enhanced noradrenergic function does not prevent situation-specific social learning but impedes the generalization of depression to heterotypic circumstances.
References
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Book

Helplessness: On Depression, Development, and Death

TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI

Depression: a new animal model sensitive to antidepressant treatments

R D Porsolt, +2 more
- 21 Apr 1977 - 
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI

The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.

TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI

Failure to Escape Traumatic Shock

TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article

Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.

TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
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