Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Corticotropin Releasing Hormone Type 2 Receptors in the Dorsal Raphe Nucleus Mediate the Behavioral Consequences of Uncontrollable Stress
Sayamwong E. Hammack,Megan J. Schmid,Matthew L. LoPresti,Andre Der-Avakian,Mary Ann Pellymounter,Alan C. Foster,Linda R. Watkins,Steven F. Maier +7 more
TL;DR: The present set of studies examined which CRH receptor subtype mediates the effects of IS and found the highly selective CRH2 receptor agonist urocortin II (Ucn II) dose-dependently caused behavioral changes associated with IS in the absence of shock.
Journal ArticleDOI
Lasting Syndrome of Depression Produced by Reduction in Serotonin Uptake During Postnatal Development: Evidence From Sleep, Stress, and Behavior
Daniela Popa,Clément Léna,Chloe Alexandre,Chloe Alexandre,Joëlle Adrien,Joëlle Adrien,Joëlle Adrien +6 more
TL;DR: Female mice treated neonatally with a highly selective serotonin reuptake inhibitor, escitalopram, exhibited signs of depression in the form of sleep anomalies, anhedonia, increased helplessness reversed by chronic antidepressant treatment, enhanced response to acute stress, and increased serotoninergic autoinhibitory feedback.
Journal ArticleDOI
On the mechanism of antidepressant-like action of berberine chloride.
TL;DR: It is demonstrated that berberine exerted antidepressant-like effect in various behavioural paradigms of despair possibly by modulating brain biogenic amines (norepinephrine, serotonin and dopamine) through nitric oxide pathway and/or sigma receptors.
Journal ArticleDOI
From the stressed adolescent to the anxious and depressed adult: investigations in rodent models.
TL;DR: The focus of the review is investigations in which adolescent rodents were exposed to chronic stressors, describing the research using social instability stress and that of other researchers using various social and non-social stressors.
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Behavioral and neurochemical phenotyping of Homer1 mutant mice: Possible relevance to schizophrenia
Karen K. Szumlinski,Kevin D. Lominac,M. J. Kleschen,Erik B. Oleson,Marlin H. Dehoff,M. K. Schwartz,P. H. Seeberg,Paul F. Worley,Peter W. Kalivas +8 more
TL;DR: Behavioral and neurochemical data derived from Homer1 mutant mice are consistent with the recent association of schizophrenia with a single‐nucleotide polymorphism in the Homer1 gene and suggest that the regulation of extracellular levels of glutamate within limbo‐corticostriatal structures by Homer 1 gene products may be involved in the pathogenesis of this neuropsychiatric disorder.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more