Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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The antidepressant activity of inositol in the forced swim test involves 5-HT2 receptors
TL;DR: In this paper, a psychopharmacological profile of inositol's behavioral effects was drawn by exploring the interactions between the drug and specific receptor agonists and antagonists in the forced swim test.
Journal ArticleDOI
Interindividual differences in active and passive behaviors in the forced-swimming test: implications for animal models of psychopathology.
TL;DR: It is concluded that a dimensional approach could improve the screening of antidepressant drugs and could aid the development of new ones by identifying the biobehavioral characteristics of responder and nonresponder subjects.
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cDNA gene expression profile of rat hippocampus after chronic treatment with antidepressant drugs.
TL;DR: A significant number and homology in gene expression were observed with the three antidepressants and many of the genes were associated with neurogenesis and synaptogenesis, including synaptophysin and neogenin.
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Inhibition of MAO and GABA: probable mechanisms for antidepressant-like activity of Nardostachys jatamansi DC. in mice.
TL;DR: The results suggested that the antidepressant-like effect of the extract may be due to interaction with GABAB receptors, resulting in decrease in the levels of GABA in mouse brain, and may have potential therapeutic value for the management of mental depression.
Journal ArticleDOI
Behavioral profiling of NPY in aggression and neuropsychiatric diseases.
Tim Karl,Herbert Herzog +1 more
TL;DR: A brief description of the latest insights into the behavioral profile of NPY in the selective lesser investigated domains such as aggression and depression-schizophrenia-related behaviors is focused on.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more