Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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The decrease in JNK- and p38-MAP kinase activity is accompanied by the enhancement of PP2A phosphate level in the brain of prenatally stressed rats.
B. Budziszewska,Magdalena Szymanska,M. Leskiewicz,Agnieszka Basta-Kaim,Lucylla Jaworska-Feil,M. Kubera,Danuta Jantas,W. Lason +7 more
TL;DR: Investigation of the levels of active phosphorylated forms of extracellular signal-regulated kinases, Jun N-terminal kinases and the p38 kinase in the hippocampus and frontal cortex in rats subjected to prenatal stress showed that prenatal stress decreased the Levels of active form of JNK and p38, but enhanced PP2A phosphatase expression and most of these changes were reversed by antidepressant drugs.
Journal ArticleDOI
Intermittent physical stress during early- and mid-adolescence differentially alters rats' anxiety- and depression-like behaviors in adulthood.
TL;DR: It appears that stress in early adolescence leads to a broader range of outcomes in adulthood, at least in male rats, while stress in mid-adolescence might have more predominant effects on risk-taking behavior (indexed by increases in open-arm activity), a possibility that merits further investigation.
Journal ArticleDOI
Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion
TL;DR: Data demonstrate an important dissociation between the antiallodynic and antidepressant effects in mice when tested in a model of neuropathic pain, which remains difficult to treat with standard analgesics.
Journal ArticleDOI
Quantitative hippocampal structural changes following electroconvulsive seizure treatment in a rat model of depression
Susanne S. Kaae,Fenghua Chen,Gregers Wegener,Gregers Wegener,Torsten M. Madsen,Jens R. Nyengaard +5 more
TL;DR: The results indicate that along with hippocampal neurogenesis, gliogenesis may also be involved in the pathophysiology of depression and in the effect of antidepressant treatment.
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Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats
Karin Wibrand,Kjetil Berge,Michaël Messaoudi,Anaïs Duffaud,Debabrata Panja,Clive R. Bramham,Lena Burri +6 more
TL;DR: Results indicate that active components in KO facilitate learning processes and provide antidepressant-like effects and suggest that KO might work through different physiological mechanisms than IMIP.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more