Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
Reads0
Chats0
TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
More filters
Journal ArticleDOI
Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression.
Luigi Cervo,Alessandro Canetta,Eleonora Calcagno,Silvia Burbassi,Giuseppina Sacchetti,Silvio Caccia,Claudia Fracasso,Diego Albani,Gianluigi Forloni,Roberto W. Invernizzi +9 more
TL;DR: The results suggest that the failure of citalopram to reduce immobility time in DBA/2J and BALB/c mice is attributable to genotype-dependent impairment of 5-HT synthesis, a mechanism underlying the response to selective serotonin reuptake inhibitors.
Journal ArticleDOI
Essential elements in depression and anxiety. Part I
Katarzyna Młyniec,Magdalena Gaweł,Urszula Doboszewska,Urszula Doboszewska,Gabriela Starowicz,Karolina Pytka,Claire L. Davies,Bogusława Budziszewska,Bogusława Budziszewska +8 more
TL;DR: Copper, selenium, manganese, iodine and vanadium are focused on in the context of enzymes which require these elements as co-factors and are involved in the underlying pathophysiology of these disorders.
Journal ArticleDOI
Comparison of the phenotype of NK1R-/- mice with pharmacological blockade of the substance P (NK1) receptor in assays for antidepressant and anxiolytic drugs
Nadia M.J. Rupniak,Emma J. Carlson,J.K. Webb,T. Harrison,R.D. Porsolt,S. Roux,C. de Felipe,SP Hunt,B. Oates,Alan Wheeldon +9 more
TL;DR: Previous observations on the phenotype of the NK1R−/− mouse are extended and a broadly similar profile following acute pharmacological blockade of the receptor is established, to underscore the limitations of currently available antagonists that are suitable for use in rat and mouse behavioural assays.
Journal ArticleDOI
Adult neurogenesis and mental illness.
TL;DR: The links between adult neurogenesis and depression seem stronger than those suggesting a relationship between new neurons and anxiety or schizophrenia, and where research needs to head in the future is discussed.
Journal ArticleDOI
The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.
TL;DR: Evidence indicating a key role for this system in modulating neurotransmission in brain circuits that subserve mood, motivation, and cognitive function is presented, suggesting that alterations in this system may contribute to affective disorders, drug addiction, and schizophrenia.
References
More filters
Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more