Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Early Life Stress Differentially Modulates Distinct Forms of Brain Plasticity in Young and Adult Mice
Inga Herpfer,Henning Hezel,Wilfried Reichardt,Kristin Clark,Julia Geiger,Claus M. Gross,Andrea Heyer,Valentin Neagu,Harsharan S. Bhatia,Hasan C. Atas,Bernd L. Fiebich,Josef Bischofberger,Carola A. Haas,Klaus Lieb,Claus Normann +14 more
TL;DR: Hippocampal volume was affected by early life stress but recovered in adulthood which corresponded to normal adult neurogenesis, however, Synaptic plasticity exhibited a delayed impairment.
Journal ArticleDOI
Antidepressant-like effect of asiaticoside in mice
Xin Liang,Yan Ni Huang,Si Wei Chen,Wen Juan Wang,Na Xu,Shan Cui,Xing Hua Liu,Hua Zhang,Yue Nan Liu,Shuang Liu,Ming Yang,Yan Dong +11 more
TL;DR: Results suggest that asiaticoside may have antidepressant-like action and significantly decreased immobility time.
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Manganese-induced atypical parkinsonism is associated with altered Basal Ganglia activity and changes in tissue levels of monoamines in the rat.
Safa Bouabid,Claire Delaville,Philippe De Deurwaerdère,Nouria Lakhdar-Ghazal,Abdelhamid Benazzouz +4 more
TL;DR: Evidence is provided that manganese intoxication is associated with impaired neurotransmission of monoaminergic systems, which is at the origin of changes in basal ganglia neuronal activity and the manifestation of motor and non-motor deficits similar to those observed in atypical Parkinsonism.
Journal ArticleDOI
In the rat forced swimming test, NA-system mediated interactions may prevent the 5-HT properties of some subacute antidepressant treatments being expressed.
TL;DR: The data suggest that the NA system mediates presynaptic inhibiting interactions on the 5-HT system, that may involve alpha(2)-receptors, and that may limit the efficacy of mixed serotonin/noradrenaline reuptake inhibition in subacute antidepressant treatments.
Journal ArticleDOI
Role of amygdala MAPK activation on immobility behavior of forced swim rats.
Tung-Yi Huang,Chih-Hung Lin +1 more
TL;DR: Results suggest that amygdala MAPK activation might play a role in the regulation of immobility behavior in rats during the forced swim test, and could provide a hint that amygdalaMAPKactivation might be involved in the formation of depression-like behavior.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more