Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Journal ArticleDOI
Sex differences in behavioral despair: relationships between behavioral despair and open field activity.
TL;DR: This study quantifies the sex differences in depression using two animal models of depression and found that the immobility levels in the Porsolt test were similar in the different stages of the estrous cycle.
Journal ArticleDOI
Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715)
TL;DR: The effects of eliprodil, an NMDA antagonist acting at polyamine sites, in behavioral and neurochemical tests predictive of antidepressant activity are examined, indicating that like other NMDA antagonists, elipRodil possesses antidepressant-like actions in preclinical tests predicting of clinical efficacy.
Journal ArticleDOI
Effects of MK-801 and antidepressant drugs in the forced swimming test in rats.
TL;DR: The results indicate that synergism may exist between antidepressants and MK-801 and that the reduction of the immobility time was also observed in those experimental paradigms in which the locomotor activity was not increased.
Journal ArticleDOI
Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT1A receptor antagonists
TL;DR: Evidence is provided that the antidepressant-like effects of 5- HT1A receptor agonists in the FST are mediated through 5-HT1A receptors, probably located postsynaptically.
Journal ArticleDOI
Effects of different stimulation parameters on the antidepressant-like response of medial prefrontal cortex deep brain stimulation in rats.
Clement Hamani,Clement Hamani,Mustansir Diwan,Silvia Isabella,Andres M. Lozano,José N. Nobrega +5 more
TL;DR: Overall, it was found that the antidepressant-like effects of DBS varied as a function of stimulation settings and target, and left unilateral stimulation was as effective as bilateral DBS.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more