Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523.
Katsura Tottori,Takashi Miwa,Yasufumi Uwahodo,Sakiko Yamada,Masami Nakai,Yasuo Oshiro,Tetsuro Kikuchi,C.A Altar +7 more
TL;DR: The antidepressant-like activity of a novel compound, OPC-14523, was investigated in comparison with the conventional antidepressants, fluoxetine and imipramine, and failed to inhibit 5-HT reuptake at oral doses below 100mg/kg.
Journal ArticleDOI
Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor
Sylwia Owczarek,Darya Kiryushko,Marianne Hald Larsen,Jette S. Kastrup,Michael Gajhede,Carmen Sandi,Vladimir Berezin,Elisabeth Bock,Vladislav Soroka +8 more
TL;DR: It is demonstrated that narpin has an antidepressive‐like effect in rats subjected to the forced swim test, suggesting that Np55‐induced signaling may be involved in synaptic plasticity in vivo.
Journal ArticleDOI
Maternal deprivation induces depressive-like behaviours only in female rats.
Vanessa Mourlon,Aurélie Baudin,Aurélie Baudin,Orianne Blanc,Orianne Blanc,Andrea C. Lauber,Bruno Giros,Laurent Naudon,Laurent Naudon,Valérie Daugé,Valérie Daugé +10 more
TL;DR: The present results suggest the use of the MD model, especially in females, as a model of the dysthymia, a mild chronic-depressive condition, which has been related to poorer maternal relationship.
Journal ArticleDOI
Cannabinoid CB1 receptor antagonism prevents neurochemical and behavioural deficits induced by chronic phencyclidine.
C. Guidali,Daniela Viganò,Stefania Petrosino,Erica Zamberletti,Natalia Realini,Giorgio Binelli,Tiziana Rubino,Vincenzo Di Marzo,Daniela Parolaro +8 more
TL;DR: An antipsychotic-like profile of the CB1 cannabinoid receptor antagonist AM251 is suggested which, by restoring the function of the endocannabinoid system, might directly or indirectly normalize some of the neurochemical maladaptations present in this schizophrenia-like animal model.
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Human interferon-α increases immobility in the forced swimming test in rats
TL;DR: It is suggested that human IFN-α has a greater potential for inducing increase of the immobility in the rat forced swimming test than humanIFN-β and -γ, and that the effect of human IFn-α might not be mediated through IFN -α/β receptors.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more