Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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In vivo effects of a GPR30 antagonist
Megan K. Dennis,Ritwik Burai,Chinnasamy Ramesh,Whitney K. Petrie,Sara N Alcon,Tapan K. Nayak,Cristian Bologa,Andrei Leitão,Eugen Brailoiu,Elena Deliu,Nae J. Dun,Larry A. Sklar,Helen J. Hathaway,Jeffrey B. Arterburn,Jeffrey B. Arterburn,Tudor I. Oprea,Eric R. Prossnitz +16 more
TL;DR: In vivo administration of G15 reveals that GPR30 contributes to both uterine and neurological responses initiated by estrogen, and the identification and characterization of a G-1 analog, G15, that binds to G PR30 with high affinity and acts as an antagonist of estrogen signaling through GPR28.
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The Forced Swim Test as a Model of Depressive-like Behavior
TL;DR: The goal of the present protocol is to describe the forced swim test (FST), which is one of the most commonly used assays for the study of depressive-like behavior in rodents, and take into account possible influences it might have on brain structure/function if brain analyses are to be carried out following this procedure.
Journal ArticleDOI
Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour.
TL;DR: Overexposure to glucocorticoid exposure programs behavioural inhibition perhaps via increased amygdalar corticotrophin-releasing hormone levels, while DEX3 also impairs coping and learning in aversive situations, possibly via altered hippocampal corticosteroid receptor levels.
Journal ArticleDOI
The tail suspension test.
Adem Can,David T. Dao,David T. Dao,Chantelle E. Terrillion,Sean C. Piantadosi,Shambhu Bhat,Todd D. Gould,Todd D. Gould +7 more
TL;DR: The details required for implementation of this test are described and a solution to the tail climbing behavior, a common problem that renders this test useless in some mouse strains, such as the widely used C57BL/6.
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Cytokines as mediators of depression: What can we learn from animal studies?
TL;DR: The value of sickness behavior as an animal model of major depressive disorder is limited, so that care should be taken in extrapolating results from the model to the human disorder, but it is concluded that immune activation and cytokines may be involved in depressive symptoms in some patients.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more