Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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Journal ArticleDOI
Fluoxetine dose and administration method differentially affect hippocampal plasticity in adult female rats.
Jodi L. Pawluski,Eva L. van Donkelaar,Zipporah Abrams,Virginie Houbart,Marianne Fillet,Harry W.M. Steinbusch,Thierry Charlier +6 more
TL;DR: The data suggest that the administration method and dose of fluoxetine can differentially affect hippocampal plasticity in the adult female rat.
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Atorvastatin prevents development of kindling by modulating hippocampal levels of dopamine, glutamate, and GABA in mice
TL;DR: Atorvastatin possesses anticonvulsant activity against electroconvulsions and was found to suppress the development of PTZ kindling, presumably altering the redox status and hippocampal levels of dopamine, glutamate, and GABA.
Journal ArticleDOI
L-tyrosine ameliorates some effects of lower body negative pressure stress.
TL;DR: The detected effects of tyrosine include an overall increase in pulse pressure and an increase in auditory event related potential amplitude, an electro-physiological correlate of attention which may indicate enhanced cognitive activation.
Journal ArticleDOI
Melatonin Augments the Effects of Fluoxetine on Depression-Like Behavior and Hippocampal BDNF–TrkB Signaling
TL;DR: It is suggested that combined fluoxetine and melatonin treatment exerts synergistic antidepressant effects possibly by restoring hippocampal BDNF–TrkB signaling as well as restoring brain-derived neurotrophic factor signaling in the hippocampus, but not in the prefrontal cortex.
Journal Article
Acute antidepressant and anxiolytic effects of simvastatin and its mechanisms in rats.
TL;DR: SimVastatin presents significant antidepressant and anxiolytic effects in rats similar to selective serotonin reuptake inhibitors, and interactions between the effects of simvastatin on indoleamine 2,3-dioxygenase enzymes, N-methyl-D-aspartic acid receptor blockade, and dopaminergic functions possibly mediate its antidepressant and anxiety effects.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
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The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more