Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Neuropeptide-Y exerts antidepressant-like effects in the forced swim test in rats.
TL;DR: The effects of neuropeptide-Y were examined in the forced swim model of depression in rats and results are consistent with that produced by serotonergic antidepressant drugs in this model.
Journal ArticleDOI
Anti-fatigue activity of polysaccharides from the fruits of four Tibetan plateau indigenous medicinal plants.
TL;DR: Water-soluble polysaccharides HRWP, LBWP, LRWP and NTWP, from the fruits of four Tibetan plateau indigenous berry plants, significantly exhibited anti-fatigue activities for the first time, through triglyceride (TG) mobilization during exercise and protecting corpuscular membrane by prevention of lipid oxidation via modifying several enzyme activities.
Journal ArticleDOI
Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism.
Valentina Gigliucci,Grainne O’Dowd,Sheena Casey,Danielle Egan,Sinead M. Gibney,Andrew Harkin +5 more
TL;DR: Observations are consistent with a role for 5-HT in mediating sustained antidepressant activity of ketamine in the FST, and molecular and cellular changes induced by ketamine may produce a rapid adaptation of 5- HT transmission which underlies the antidepressant response.
Journal ArticleDOI
Are Wistar-Kyoto rats a genetic animal model of depression resistant to antidepressants?
TL;DR: The subsensitivity to imipramine observed in Wistar-Kyoto rats can not be primarily explained by pharmacokinetic differences, and does not appear to be related to the monoaminergic systems.
Journal ArticleDOI
New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Nesrin Gökhan-Kelekçi,Semra Koyunoğlu,Samiye Yabanoglu,Kemal Yelekçi,Özen Özgen,Gulberk Ucar,Kevser Erol,Engin Kendi,Akgül Yeşilada +8 more
TL;DR: A new series of pyrazoline derivatives were prepared starting from a quinazolinone ring and evaluated for antidepressant, anxiogenic and MAO-A and -B inhibitory activities by in vivo and in vitro tests, respectively, and it appears that the binding interactions for this class of compounds are mostly hydrophobic.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
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The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more