Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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The effects of antidepressant treatment in prenatally stressed rats support the glutamatergic hypothesis of stress-related disorders.
Jordan Marrocco,Marie Line Reynaert,Eleonora Gatta,Cecilia Gabriel,Elisabeth Mocaer,Silvia Di Prisco,Elisa Merega,Anna Pittaluga,Ferdinando Nicoletti,Stefania Maccari,Sara Morley-Fletcher,Jérôme Mairesse +11 more
TL;DR: Antidepressant treatment corrected abnormalities in anxiety-/depression-like behavior and social memory performance in PRS rats, offering the pharmacological demonstration that glutamatergic hypofunction in the ventral hippocampus lies at the core of the pathological phenotype caused by early life stress and represents an attractive pharmacological target for novel therapeutic strategies.
Journal ArticleDOI
Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats
Claudia A. Grillo,Gerardo G. Piroli,Kris F. Kaigler,Steven P. Wilson,Marlene A. Wilson,Lawrence P. Reagan +5 more
TL;DR: Data support the hypothesis for an increased risk for mood disorders in obesity, which may be related to decreased expression of hippocampal and amygdalar brain-derived neurotrophic factor BDNF.
Journal Article
Environmental-Enrichment–Related Variations in Behavioral, Biochemical, and Physiologic Responses of Sprague–Dawley and Long Evans Rats
TL;DR: The data support the claim that environmental enrichment may render animals more resilient to challenges and indicate that stock- and group-associated differences in several indices occur in association with enrichment.
Journal ArticleDOI
Sex Differences in the Regulation of Serotonergic Transmission and Behavior in 5-HT Receptor Knockout Mice
Michelle D Jones,Irwin Lucki +1 more
TL;DR: Female 5- HT1B receptor knockout mice demonstrate a sex-linked disinhibition of 5-HT release that sustained higher baseline levels of hippocampal5-HT and behavioral vulnerability to 5-ht depletion.
Journal ArticleDOI
Deep learning-based behavioral analysis reaches human accuracy and is capable of outperforming commercial solutions.
Oliver Sturman,Oliver Sturman,Lukas von Ziegler,Lukas von Ziegler,Christa Schläppi,Christa Schläppi,Furkan Akyol,Furkan Akyol,Mattia Privitera,Mattia Privitera,Daria Slominski,Daria Slominski,Christina Grimm,Christina Grimm,Laetitia Thieren,Valerio Zerbi,Valerio Zerbi,Benjamin F. Grewe,Benjamin F. Grewe,Johannes Bohacek,Johannes Bohacek +20 more
TL;DR: This work provides a set of videos—carefully annotated by several human raters— of three widely used behavioral tests, and develops supervised machine learning classifiers that integrate the skeletal representation with the manual annotations, and shows that the resulting machine learning approach eliminates variation both within and between human annotators.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more