Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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A Single Neonatal Injury Induces Life-Long Deficits in Response to Stress
TL;DR: Adding to mounting evidence that neonatal injury in the absence of analgesics has adverse effects that are both long-term and polysystemic, changes in stress-related behavior were opioid-dependent.
Journal ArticleDOI
Voluntary Exercise During Adolescence Mitigated Negative the Effects of Maternal Separation Stress on the Depressive-Like Behaviors of Adult Male Rats: Role of NMDA Receptors
TL;DR: The results showed that FLX/voluntary RW exercise during adolescence could normalize altered expression of Grin2a in the hippocampus of adult rats, highlighting the importance of adolescence in treating stressed animals with FLX or voluntary RW exercise to alleviate the depressive effects of ELS.
Journal ArticleDOI
Interleukin-1 affects the behavioral despair response in rats by an indirect mechanism which requires endogenous CRF.
Sonia del Cerro,José Borrell +1 more
TL;DR: The results suggest the existence of a complex interface between immune, neuroendocrine and behavioral regulation and shows that the release of cerebral CRF, probably from the hypothalamus, may mediate the behavioral effect promoted by IL-1.
Journal ArticleDOI
Aging with Traumatic Brain Injury: Effects of Age at Injury on Behavioral Outcome following Diffuse Brain Injury in Rats
Rachel K. Rowe,Jenna M. Ziebell,Jenna M. Ziebell,Jenna M. Ziebell,Jordan L. Harrison,Jordan L. Harrison,Jordan L. Harrison,L. Matthew Law,L. Matthew Law,P. David Adelson,P. David Adelson,P. David Adelson,Jonathan Lifshitz +12 more
TL;DR: The interplay of age at injury and aging with an injury are translationally important factors that influence behavioral performance as a quality of life metric and more complete understanding of these factors can direct rehabilitation efforts and personalized medicine for TBI survivors.
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Behavioral evaluation of adult rats exposed in utero to maternal epileptic seizures.
Daiana Correia Lima,Tiago Gurgel do Vale,Gustavo Adolfo Argañaraz,Pedro Paulo Vasconcelos Varella,Roberto Frussa-Filho,Esper A. Cavalheiro,Maria da Graça Naffah-Mazzacoratti,Débora Amado +7 more
TL;DR: It is suggested that "in utero" exposure to maternal seizures can produce motor deficits in adult life, perhaps as a result of fetal hypoxia.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more