Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
Reads0
Chats0
TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
More filters
Journal ArticleDOI
Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model: effects on neurotrophic factors and neuronal density
Inmaculada Tasset,Francisco J. Medina,Ignacio Jimena,Eduardo Agüera,Félix Gascón,Montserrat Feijóo,Fernando Sánchez-López,Evelio Luque,J. Peña,René Drucker-Colín,Isaac Túnez +10 more
TL;DR: ELFEF alleviates 3NP-induced brain injury and prevents loss of neurons in rat striatum, thus showing considerable potential as a therapeutic tool.
Journal ArticleDOI
Pharmacological characterization of FR194921, a new potent, selective, and orally active antagonist for central adenosine A1 receptors.
Takuya Maemoto,Miho Tada,Takuma Mihara,Noriko Ueyama,Hideaki Matsuoka,Katsuya Harada,Takayuki Yamaji,Kiyoharu Shirakawa,Satoru Kuroda,Atsushi Akahane,Akinori Iwashita,Nobuya Matsuoka,Seitaro Mutoh +12 more
TL;DR: Oral administration of FR194921 dose-dependently ameliorated the hypolocomotion induced by the A1 receptor agonist N6-cyclopentyladenosine in rats, indicating this compound exerts A1-antagonistic action in vivo.
Journal ArticleDOI
Potential antidepressant properties of Radix Polygalae (Yuan Zhi).
TL;DR: The results indicate that the presence of oligosaccharide esters such as DISS and TEA in this herb may be responsible for the cytoprotective activity effects.
Journal ArticleDOI
Comparative study of Rhodiola preparations on behavioral despair of rats.
Alexander Panossian,N. Nikoyan,N. Ohanyan,Areg Hovhannisyan,H. Abrahamyan,E. Gabrielyan,G. Wikman +6 more
TL;DR: Piperine in combination with Rhodiola (RPE) distorts pharmacological effect of Rhodiola most probably due to changes of pharmacokinetic profile of rhodioloside and rosavin, and RPE cannot provide predictable therapeutic effect due to herb-herb interaction.
Journal ArticleDOI
Improvement of phencyclidine-induced social behaviour deficits in rats: Involvement of 5-HT1A receptors
Shikha Snigdha,Joanna C. Neill +1 more
TL;DR: The findings suggest that the beneficial effects of drugs such as aripiprazole and fluoxetine on PCP-induced social behaviour deficits, a potential model of negative symptoms of schizophrenia, may be a consequence of modifications of the serotonergic system, in particular through an interaction with 5-HT(1A) receptors.
References
More filters
Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more