Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Assessing spatial learning and memory in rodents.
TL;DR: Several allocentric assessment methods for rodents are reviewed and compared with the Morris water maze and it is concluded that, on balance, the MWM has more advantages than disadvantages and compares favorably with other allocentric navigation tasks.
Journal ArticleDOI
Leptin: A potential novel antidepressant
TL;DR: This article showed that rats exposed to chronic unpredictable stress and chronic social defeat exhibit low leptin levels in plasma and increased neuronal activation in limbic structures, particularly in the hippocampus, and infusion of leptin into the hypothalamus decreased body weight but had no effect on FST behavior.
Journal ArticleDOI
Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression.
Amelia J. Eisch,Carlos A. Bolaños,Joris de Wit,Ryan D Simonak,Cindy M. Pudiak,Michel Barrot,Joost Verhaagen,Eric J. Nestler +7 more
TL;DR: It is shown that BDNF in the ventral tegmental area-nucleus accumbens (VTA-NAc) pathway is also involved in the development of a depression-like phenotype, and this interpretation is intriguing in that it suggests a role for BD NF in the VTA- NAc that is opposite of the proposed role for the molecule in the hippocampus.
Journal ArticleDOI
Cortical 5-HT2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice
Noelia V. Weisstaub,Mingming Zhou,Alena Lira,Evelyn K. Lambe,Evelyn K. Lambe,Javier González-Maeso,Jean-Pierre Hornung,Etienna Sibille,Etienna Sibille,Mark D. Underwood,Shigeyoshi Itohara,William T. Dauer,Mark S. Ansorge,Emanuela Morelli,J. John Mann,Miklós Tóth,George K. Aghajanian,Stuart C. Sealfon,René Hen,Jay A. Gingrich +19 more
TL;DR: It is demonstrated that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors.
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Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats.
TL;DR: The results suggest that repeated CORT injections warrant further investigation as an animal model to study the role of stress in depression.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more