Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety.
Ana M. Basso,Natalie A. Bratcher,Kelly B. Gallagher,Marlon D. Cowart,Chen Zhao,Minghua Sun,Timothy A. Esbenshade,Michael E. Brune,Gerard B. Fox,Martin Schmidt,Christine A. Collins,Andrew J. Souers,Rajesh R. Iyengar,Anil Vasudevan,Philip R. Kym,Arthur A. Hancock,Lynne E. Rueter +16 more
TL;DR: The lack of efficacy with four structurally different MCH-1 receptor antagonists does not support a role for therapeutic treatment of depression/anxiety via this mechanism of action.
Journal ArticleDOI
Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model.
Tong Wang,Cuige Shi,Xiaoxiao Li,Pan Zhang,Bo Liu,Hao Wang,Yongjun Wang,Yutao Yang,Yan Wu,Hui Li,Zhi-Qing David Xu +10 more
TL;DR: Data suggest that OXT plays an antidepressant role by, at least in part, modulating HPA axis via TrkB in PVN of PPD rats.
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The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat.
TL;DR: It is demonstrated that CRF1 receptor blockade by CRA 1000 has antidepressant-like effects, does not have a robust anti-anxiety effect in non-stressed animals, but does have anxiolytic- like effects in more complex tasks, which can be observed also after denervation of the locus coeruleus projections.
Journal ArticleDOI
A potential antidepressant activity of SA4503, a selective sigma 1 receptor agonist.
TL;DR: The suggestion that SA4503 may have potential antidepressive properties is supported, as it shows a synergistic effect with imipramine and decreased the immobility time in the forced swimming test in rats.
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Behavioral characteristics of SART-stressed mice in the forced swim test and drug action.
TL;DR: The SART stress technique may be a potential model to investigate the relationship between stress and depression with complex symptoms like excessive emotion- and anxiety-related depression.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more