Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Journal ArticleDOI
Neuropathic pain is associated with depressive behaviour and induces neuroplasticity in the amygdala of the rat.
Leonor Gonçalves,Rui Silva,Filipa Pinto-Ribeiro,José M. Pêgo,João Bessa,Antti Pertovaara,Nuno Sousa,Armando Almeida +7 more
TL;DR: It is demonstrated that neuropathic pain promotes generation of new neurons in the AMY, and it is proposed that these neuroplastic changes might contribute for the development of depressive-like symptoms that are usually present in prolonged pain syndromes in humans.
Journal ArticleDOI
Anxiolytic- and antidepressant-like properties of ketamine in behavioral and neurophysiological animal models
TL;DR: It is found that ketamine decreased "behavioral despair" in the forced swim test, a widely used rats model of antidepressant drug action, and this effect was not confounded by side-effects on general activity, and was comparable to that of a standard antidepressant drug, fluoxetine.
Journal ArticleDOI
Piperine from the Fruits of Piper longum with Inhibitory Effect on Monoamine Oxidase and Antidepressant-Like Activity
Seon A Lee,Seong Su Hong,Xiang Hua Han,Ji Sang Hwang,Gab Jin Oh,Kyong Soon Lee,Myung Koo Lee,Bang Yeon Hwang,Jai Seup Ro +8 more
TL;DR: The results suggest that piperine possesses potent antidepressant-like properties that are mediated in part through the inhibition of MAO activity, and therefore represent a promising pharmacotherapeutic candidate as an antidepressant agent.
Journal ArticleDOI
Cerebral correlates of depressed behavior in rats, visualized using 14C-2-deoxyglucose autoradiography.
TL;DR: 2DG findings of identical metabolic changes in each of the models indicate that these changes are not idiosyncratic to a particular model; rather, they correlate with a generalizable state of depressed exploratory behavior in rats.
Journal ArticleDOI
Antidepressant-like effects in various mice strains in the forced swimming test.
TL;DR: The FST results have shown that Swiss mice are the most sensitive strain to detect 5-HT and/or NA treatment, and showed that drug sensitivity is genotype dependent.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more