Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans].
Corinne Comoy,Christophe Marot,T. Podona,M.‐L. Baudin,Luc Morin-Allory,Gérald Guillaumet,Pfeiffer Bruno,D. H. Caignard,Pierre Renard,Marie-Claire Rettori,Gerard Adam,B Guardiola-Lemaı̂tre +11 more
TL;DR: R rigid spirobenzopyran analogues designed from the pharmacophore models of Mellin and selected via a quantitative structure-activity relationship approach mainly based on similarity indices proved in vitro to be a full agonist and in vivo to be active in various comportmental tests predictive of psychotropic activity.
Journal ArticleDOI
Memantine ameliorates depressive-like behaviors by regulating hippocampal cell proliferation and neuroprotection in olfactory bulbectomized mice
Kohei Takahashi,Osamu Nakagawasai,Wataru Nemoto,Shogo Kadota,Jinichi Isono,Takayo Odaira,Wakana Sakuma,Yuichiro Arai,Takeshi Tadano,Koichi Tan-No +9 more
TL;DR: The results suggest that MEM‐induced antidepressant effects are associated with enhanced hippocampal cell proliferation and neuroprotection via the PKA‐ERK‐CREB‐BDNF/Bcl‐2‐caspase‐3 pathway and increased DA levels.
Journal ArticleDOI
Antinociceptive effects of tricyclic antidepressants and their noradrenergic metabolites.
TL;DR: The overall results show that preferentially noradrenergic tricyclics induced an antinociceptive effect comparable with that of mixed tricyCLics, indicating that nor adrenaline reuptake plays an important role intricyclic-induced ant inociception.
Journal ArticleDOI
Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats.
Yiyun Liu,Xinyu Zhou,Lining Yang,Haiyang Wang,Yuqing Zhang,Juncai Pu,Lanxiang Liu,Siwen Gui,Li Zeng,Jianjun Chen,Chanjuan Zhou,Peng Xie +11 more
TL;DR: The results of this study suggest that repeated social defeat can lead to metabolic changes and depression-like behavior in rats.
Journal Article
Mechanism of synergistic action following co- treatment with pramipexole and fluoxetine or sertraline in the forced swimming test in rats
Zofia Rogóż,Grazyna Skuza +1 more
TL;DR: It is indicated that co-administration of pramipexole and fluoxetine or sertraline may induce a more pronounced antidepressive activity than does treatment with pramipingxole alone, and that in addition to other mechanisms, dopamine D(2/3) and 5-HT(1A) receptors may contribute to the antidepressant-like activity of pr amipexoles and flu oxetineor sertrals in the forced swimming test in rats
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more