Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Anxiolytic and antidepressant actions of somatostatin: the role of sst2 and sst3 receptors.
Elif Engin,Dallas Treit +1 more
TL;DR: The results suggest a clinical role for somatostatin agonists for the simultaneous treatment of anxiety and depression, which are often comorbid.
Journal ArticleDOI
Behavioural and neurotoxic effects of ayahuasca infusion (Banisteriopsis caapi and Psychotria viridis) in female Wistar rat
Aline Pic-Taylor,Luciana Gueiros da Motta,Juliana Alves de Morais,Willian Melo Junior,Alana de Fátima Andrade Santos,Leandro Ambrósio Campos,Márcia Renata Mortari,Marcus Vinicius von Zuben,Eloisa Dutra Caldas +8 more
TL;DR: The results suggest that ayahuasca has antidepressant properties in Wistar female at high doses, an effect that should be further investigated.
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Motor lateralization, behavioral despair and dopaminergic brain asymmetry after prenatal stress.
TL;DR: The present study suggests that lateralization of behavior and emotion during adulthood can be modified by prenatal variables, and suggests that the biological dopaminergic inervation of n.
Journal ArticleDOI
Mimosa pudica may possess antidepressant actions in the rat.
TL;DR: Data suggest that M. pudica produces antidepressant effects in the rat, and produced an antide-pressant-like profile similar to two tricyclic antidepressants.
Journal ArticleDOI
A pretest procedure reliably predicts performance in two animal models of inescapable stress.
TL;DR: There was no correlation between rats that displayed helplessness following inescapable tailshock and the rats that demonstrated "behavioral despair" on a later test.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more