Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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Journal ArticleDOI
Signs of attenuated depression-like behavior in vasopressin deficient Brattleboro rats
TL;DR: Data obtained in vasopressin deficient rats show that vasopressingin is involved in the development of depression-like behavior, in particular of the coping style and anhedonia, and it is suggested that brain vasopressesinergic circuits distinct from those regulating the HPA axis are involved in generating depression- like behavior.
Journal ArticleDOI
Increased oxidative stress in prefrontal cortex and hippocampus is related to depressive-like behavior in streptozotocin-diabetic rats
Helen de Morais,Camila Pasquini de Souza,Luisa Mota da Silva,Daniele Maria Ferreira,Maria Fernanda de Paula Werner,Roberto Andreatini,Joice Maria da Cunha,Janaina Menezes Zanoveli +7 more
TL;DR: The data show that treatment of streptozotocin-induced diabetic (DBT) rats with INS prevented the blood glucose increase, reduced the immobility time, an antidepressant-like behavior, and normalized the reduced weight gain in DBT rats, and provide further evidence of the importance of oxidative stress in PFC and HIP in the pathophysiology of depression related to diabetes.
Journal ArticleDOI
Repeated rat-forced swim test: Reducing the number of animals to evaluate gradual effects of antidepressants
TL;DR: Repeated rat-FST seemed suitable to detect short and long term effects of selective serotonin reuptake inhibitors, or other ADT, thus reducing the number of animals used in the screenings of this type of compounds.
Journal ArticleDOI
Antidepressant-like properties of α2-containing GABAA receptors
TL;DR: GABAergic inhibition acting via α2-containing GABA(A) receptors has an antidepressant-like effect in vivo and these receptors represent a specific molecular substrate that can regulate depressive-like states, and may represent a novel target for the development of more effective antidepressants.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more