Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
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Antidepressant-like Effect of Tetrahydroisoquinoline Amines in the Animal Model of Depressive Disorder Induced by Repeated Administration of a Low Dose of Reserpine: Behavioral and Neurochemical Studies in the Rat
TL;DR: It is suggested that both TIQ and 1MeTIQ may be effective for the therapy of depression in clinic as new antidepressants which, when administered peripherally easily penetrate the blood–brain barrier, and as endogenous compounds may not have adverse side effects.
Journal ArticleDOI
Behavioural changes after different stress paradigms: prepulse inhibition increased after physical, but not emotional stress.
TL;DR: Physical and emotional stress induce differential changes on locomotor activity, startle response and PPI, i.e., the role of the mesolimbic dopamine system and opioid systems is discussed.
Journal ArticleDOI
High-Efficacy 5-HT1A Agonists for Antidepressant Treatment: A Renewed Opportunity
Jean Louis Maurel,Jean-Marie Autin,Philippe Funes,Adrian Newman-Tancredi,Francis Colpaert,Bernard Vacher +5 more
TL;DR: After acute oral administration in rats, 9 totally reverses immobility in the forced swimming test and produces behaviors characteristic of5-HT1A receptor activation, suggesting that 9 discriminates between distinct populations of 5- HT1A receptors.
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Behavioral effects of ketamine and toxic interactions with psychostimulants
TL;DR: In the toxic dose psychostimulant-KT groups, KT attenuated the severity of seizures dose-dependently, and the mortality rate was significantly increased by co-treatment with the high dose KT, which demonstrated that the lethal effects of these psychostIMulants were increased by KT.
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Role of genotype and dopamine receptors in behaviour of inbred mice in a forced swimming test
TL;DR: A different role for D1 and D2 dopamine receptors in the regulation of swimming in the mouse is suggested, with the effects being genotype dependent.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
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The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more