Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
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TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
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Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats.
TL;DR: A role for the endocannabinoid system in the neurobiology of depression is supported and the use of URB597 is suggested as a new therapeutic tool with antidepressant properties.
Journal ArticleDOI
Psychopharmacology of dopamine: the contribution of comparative studies in inbred strains of mice
TL;DR: Results obtained in mice of the C57BL/6 (C57) and DBA/2 (DBA) inbred strains which have been used for studies of the behavioral pharmacology of dopamine (DA) and investigated for the functional and anatomical characteristics of their brain DA systems are evaluated.
Journal ArticleDOI
Targeting drugs to the brain by redox chemical delivery systems
TL;DR: In vivo and in vitro studies and preliminary clinical data of several novel derivatives have been promising, which could lead to a practical use of the redox CDSs after proper pharmaceutical development.
Journal ArticleDOI
Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: Implication of glutamate excitotoxicity and oxidative stress
Daiane Cattani,Patrícia Acordi Cesconetto,Mauren K. Tavares,Eduardo Benedetti Parisotto,Paulo Alexandre de Oliveira,Carla Elise Heinz Rieg,Marina Concli Leite,Rui Daniel Prediger,Nestor Cubas Wendt,Guilherme Razzera,Danilo Wilhelm Filho,Ariane Zamoner +11 more
TL;DR: Results showed that GBH exposure during both prenatal and postnatal periods causes oxidative stress, affects cholinergic and glutamatergic neurotransmission in offspring hippocampus from immature and adult rats, and subchronic exposure to the pesticide alters the serum levels of the astrocytic protein S100B.
Journal ArticleDOI
17β-Estradiol replacement in young, adult and middle-aged female ovariectomized rats promotes improvement of spatial reference memory and an antidepressant effect and alters monoamines and BDNF levels in memory- and depression-related brain areas
Ágata Kiss,Ana Marcia Delattre,Sofia Isabel Ribeiro Pereira,Ruither G. Carolino,Raphael E. Szawka,Raphael E. Szawka,Janete Aparecida Anselmo-Franci,Silvio M. Zanata,Anete Curte Ferraz +8 more
TL;DR: The notion that the beneficial effects of 17β-estradiol over spatial reference memory and depressive-like behavior are evident only when hormone therapy occurs at early ages and early stages of hormonal decline is supported.
References
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Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more