Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
Reads0
Chats0
TLDR
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.About:
This article is published in European Journal of Pharmacology.The article was published on 1978-02-15. It has received 3030 citations till now. The article focuses on the topics: Mianserin & Iprindole.read more
Citations
More filters
Journal ArticleDOI
Antidepressant-like effects of the acute and chronic administration of nicotine in the rat forced swimming test and its interaction with flouxetine
TL;DR: Data suggest that NIC has an antidepressant action that is expressed faster than FLX but remains the same later, suggesting that cholinergic–serotonergic interactions could play an important role in the treatment of depression.
Journal ArticleDOI
Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression
Lothar Lindemann,Porter Richard Hugh Phillip,Sebastian H. Scharf,Basil Kuennecke,Andreas Bruns,Markus von Kienlin,Anthony C. Harrison,Axel Paehler,Christoph Funk,Andreas Gloge,Manfred Schneider,Neil Parrott,Liudmila Polonchuk,Urs Niederhauser,Stephen R. Morairty,Thomas S. Kilduff,Eric Vieira,Sabine Kolczewski,Juergen Wichmann,Thomas Hartung,Michael Honer,Edilio Borroni,Jean-Luc Moreau,Eric Prinssen,Will Spooren,Joseph G. Wettstein,Georg Jaeschke +26 more
TL;DR: Basimglurant has favorable drug-like properties, a differentiated molecular mechanism of action, and antidepressant-like features that suggest the possibility of also addressing important comorbidities of MDD including anxiety and pain as well as daytime sleepiness and apathy or lethargy.
Journal ArticleDOI
Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors
Kazufumi Hirano,Ryohei Kimura,Yumi Sugimoto,Jun Yamada,Shinya Uchida,Yasuhiro Kato,Hisakuni Hashimoto,Shizuo Yamada +7 more
TL;DR: The present study has provided the first in vivo evidences to support that fluvoxamine, fluoxetine, parxetine and sertraline orally administered bind to the pharmacologically relevant brain SERT in mice and that their SERT‐binding characteristics is closely associated with the pharmacokinetics and inhibition of marble‐burying behaviour.
Journal ArticleDOI
Effects of Fish Oil on the Central Nervous System: A New Potential Antidepressant?
Katya Naliwaiko,Renata Lins Fuentes Araújo,R.V. da Fonseca,J.C. Castilho,Roberto Andreatini,M.I. Bellissimo,Brás H. de Oliveira,E. Martins,Rui Curi,L C Fernandes,Anete Curte Ferraz +10 more
TL;DR: It is concluded that lifelong intake of FO was able to induce an antidepressant effect with EPA and DHA concentration increased in the cerebral cortex and hippocampus.
Journal ArticleDOI
Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour.
TL;DR: Findings indicate that stress-induced corticosterone and consequent activation of hepatic TDO, tryptophan metabolism and production of kynurenine provoke a depression-related behavioural phenotype and TDO may represent a promising target for the treatment of depression associated with stress-related disorders in which there is evidence for KP activation.
References
More filters
Book
Helplessness: On Depression, Development, and Death
TL;DR: In this article, the authors proposed a learned-helplessness model of depression and developed a set of guidelines for depression and learned helplessness, including depression, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability.
Journal ArticleDOI
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Journal ArticleDOI
The making and breaking of affectional bonds. I. Aetiology and psychopathology in the light of attachment theory. An expanded version of the Fiftieth Maudsley Lecture, delivered before the Royal College of Psychiatrists, 19 November 1976.
TL;DR: Though attachment theory incorporates much psychoanalytic thinking, many of its principles derive from ethology, cognitive psychology and control theory, and it conforms to the ordinary criteria of a scientific discipline.
Journal ArticleDOI
Failure to Escape Traumatic Shock
TL;DR: Dogs which had first learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box, supporting a learned "helplessness" explanation of interference with escape responding.
Journal Article
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
TL;DR: The tubular configuration of EXP-561 may be the most appropriate for blocking serotonin uptake and the conformation defined by the combination resulting from superimposition of the CP-24-441 and desipramine structures is apparently optimal for blocking norepinephrine uptake.
Related Papers (5)
Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more