Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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Plasma β-amyloid in Alzheimer’s disease and vascular disease
Shorena Janelidze,Erik Stomrud,Sebastian Palmqvist,Henrik Zetterberg,Henrik Zetterberg,Danielle van Westen,Andreas Jeromin,Linan Song,David Hanlon,Cristina Tan Hehir,David Baker,Kaj Blennow,Oskar Hansson +12 more
TL;DR: Plasma Aβ is overtly decreased during the dementia stage of AD indicating that prominent changes in Aβ metabolism occur later in the periphery compared to the brain, and increased levels of Aβ in plasma are associated with vascular disease.
Journal ArticleDOI
FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease
Lisa Mosconi,Rachel Mistur,Remigiusz Switalski,Wai Hon Tsui,Wai Hon Tsui,Lidia Glodzik,Yi Li,Elizabeth Pirraglia,Susan De Santi,Barry Reisberg,Thomas Wisniewski,Mony J. de Leon,Mony J. de Leon +12 more
TL;DR: First clinicopathological series of longitudinal FDG-PET scans in post-mortem (PM) verified cognitively normal elderly followed to the onset of Alzheimer’s-type dementia (DAT), and in patients with mild DAT with progressive cognitive deterioration.
Journal ArticleDOI
Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging.
TL;DR: Arterial spin‐labeled magnetic resonance imaging was found to be an effective tool for characterizing flow decreases accompanying Alzheimer's disease and the absence of ionizing radiation or injection and the ability to obtain high quality anatomical images within the same scanning session make arterial spin labeling an attractive technique.
Journal ArticleDOI
Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented.
TL;DR: Moves of delayed recall and executive functions were the best discriminators between those who will manifest AD 1.5 years later and those who would remain nondemented, relevant for the early detection of AD and, therefore, for prevention and early intervention trials.
Journal ArticleDOI
Imaging amyloid deposition in Lewy body diseases
Stephen N. Gomperts,Dorene M. Rentz,Erin K. Moran,John A. Becker,Joseph J. Locascio,William E. Klunk,Chet Mathis,David R. Elmaleh,Timothy M. Shoup,Alan J. Fischman,Bradley T. Hyman,John H. Growdon,Keith A. Johnson +12 more
TL;DR: Global cortical amyloid burden is high in dementia with Lewy bodies (DLB) but low in Parkinson disease dementia, and data suggest that β-amyloid may contribute selectively to the cognitive impairment of DLB and may contribute to the timing of dementia relative to the motor signs of parkinsonism.
References
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Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
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Development of a Rating Scale for Primary Depressive Illness
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Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.