Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment.
Gaël Chételat,Béatrice Desgranges,Vincent de La Sayette,Fausto Viader,Francis Eustache,Jean-Claude Baron +5 more
TL;DR: This pattern of gray matter loss in mild cognitive impairment agrees with but considerably expands upon previous region-of-interest based MRI studies, and is highly consistent with the course of neurofibrillary tangles across aging and Alzheimer's disease.
Journal ArticleDOI
Preserved Cognition in Patients With Early Alzheimer Disease and Amnestic Mild Cognitive Impairment During Treatment With Rosiglitazone
G. Stennis Watson,Brenna Cholerton,Mark A. Reger,Laura D. Baker,Stephen R. Plymate,Stephen R. Plymate,Sanjay Asthana,Mark A. Fishel,J. Jacob Kulstad,Pattie S. Green,David G. Cook,David G. Cook,David G. Cook,Steven E. Kahn,Steven E. Kahn,Michelle L. Keeling,Suzanne Craft +16 more
TL;DR: Preliminary support is provided that rosiglitazone may offer a novel strategy for the treatment of cognitive decline associated with AD, consistent with recent reports that plasma Abeta42 decreases with progression of AD.
Journal ArticleDOI
Dementia After Stroke The Framingham Study
Cristina S. Ivan,Sudha Seshadri,Alexa S. Beiser,Rhoda Au,Carlos S. Kase,Margaret Kelly-Hayes,Philip A. Wolf +6 more
TL;DR: Stroke increases a subject's risk of dementia as compared with age- and sex-matched controls and primary and secondary prevention of stroke should significantly decrease the risk of all dementia.
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Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD.
Yuecheng Xu,C. R. Jack,P. C. O'Brien,Emre Kokmen,Glenn E. Smith,Robert J. Ivnik,B. F. Boeve,R. G. Tangalos,Ronald C. Petersen +8 more
TL;DR: Despite the theoretical rationale for the superiority of entorhinal measurements in early AD, the authors found MRI measurements of the hippocampus and entorHinal cortex were approximately equivalent at intergroup discrimination.
Journal ArticleDOI
Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia.
Gregory A. Jicha,Joseph E. Parisi,Dennis W. Dickson,Kris Johnson,Ruth H. Cha,Robert J. Ivnik,Eric G. Tangalos,Bradley F. Boeve,David S. Knopman,Heiko Braak,Ronald C. Petersen +10 more
TL;DR: The neuro Pathologic outcome of amnestic MCI following progression to dementia is heterogeneous, and it includes AD at a high frequency, and complex neuropathologic findings including 2 or more distinct pathologic entities contributing to dementia may be common in community-based cohorts.
References
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Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
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Development of a Rating Scale for Primary Depressive Illness
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M. P. Lawton,Elmne M. Brody +1 more
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