Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
Reads0
Chats0
TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
Citations
More filters
Journal ArticleDOI
Psychiatric phenomena in Alzheimer's disease. IV, Disorders of behaviour
TL;DR: Out of a sample of 178 patients with AD, aggression was present in 20%, wandering in 19%, binge-eating in 10%, hyperorality in 6%, urinary incontinence in 48%, and sexual disinhibition in 7%.
Journal ArticleDOI
Validation of clinical diagnostic criteria for Alzheimer's disease.
TL;DR: Research clinical diagnostic criteria for SDAT, even in its mild stage, are valid, and it is concluded that research clinical diagnostic guidelines for AD are valid.
Journal ArticleDOI
Early-versus late-onset Alzheimer's disease: more than age alone.
Esther L.G.E. Koedam,Vivian Lauffer,Annelies E. van der Vlies,Wiesje M. van der Flier,Philip Scheltens,Yolande A.L. Pijnenburg +5 more
TL;DR: Patients with early-onset AD often present with a non-memory phenotype, of which apraxia/visuospatial dysfunction is the most common presenting symptom, which should be considered in the clinical differential diagnosis of early-ONSet dementia.
Journal ArticleDOI
Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease
Michael F. Egan,James Kost,Tiffini Voss,Yuki Mukai,Paul S. Aisen,Jeffrey L. Cummings,Pierre N. Tariot,Bruno Vellas,Christopher H. van Dyck,Mercè Boada,Ying Zhang,Wen Li,Christine Furtek,Erin Mahoney,Lyn Harper Mozley,Yi Mo,Cyrille Sur,David Michelson +17 more
TL;DR: Verubecestat did not improve clinical ratings of dementia among patients with prodromal Alzheimer's disease, and some measures suggested that cognition and daily function were worse among patients who received verubECestat than among those who received placebo.
References
More filters
Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Studies of illness in the aged. the index of adl: a standardized measure of biological and psychosocial function.
TL;DR: The Index of ADL as discussed by the authors was developed to study results of treatment and prognosis in the elderly and chronically ill. Grades of the Index summarize over-all performance in bathing, dressing, going to toilet, transferring, continence, and feeding.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Journal ArticleDOI
Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.