Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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Semantic memory impairment in Alzheimer's disease: failure of access or degraded knowledge?
TL;DR: Analysis of the errors made by each patient across the different tests, revealed a significant correspondence between the individual items, offering compelling evidence that the semantic breakdown in DAT is caused by storage degradation.
Journal ArticleDOI
Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease
Clifford R. Jack,Ronald C. Petersen,Yuecheng Xu,Peter C. O'Brien,Glenn E. Smith,Robert J. Ivnik,Eric G. Tangalos,Emre Kokmen +7 more
TL;DR: A statistically significant yearly decline in hippocampal volume and an increase in temporal horn volume was identified in elderly control subjects who represent typical aging individuals, and these rates were approximately 2.5 times greater in patients with AD than in individually age- and gender-matched control subjects.
Journal ArticleDOI
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
Gernot Kleinberger,Yoshinori Yamanishi,Marc Suárez-Calvet,Eva Czirr,Ebba Lohmann,Ebba Lohmann,Ebba Lohmann,Elise Cuyvers,Hanne Struyfs,Nadine Pettkus,Andrea Wenninger-Weinzierl,Fargol Mazaheri,Sabina Tahirovic,Alberto Lleó,Daniel Alcolea,Juan Fortea,Michael Willem,Sven Lammich,José Luis Molinuevo,Raquel Sánchez-Valle,Anna Antonell,Alfredo Ramirez,Michael T. Heneka,Kristel Sleegers,Julie van der Zee,Jean-Jacques Martin,Sebastiaan Engelborghs,Asli Demirtas-Tatlidede,Henrik Zetterberg,Christine Van Broeckhoven,Hakan Gurvit,Tony Wyss-Coray,John Hardy,Marco Colonna,Christian Haass,Christian Haass +35 more
TL;DR: It is reported that missense mutations associated with FTD and FTD-like syndrome reduce TREM2 maturation, abolish shedding by ADAM proteases, and impair the phagocytic activity of TREM1-expressing cells.
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Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71.
Alessandra Castegna,Michael Aksenov,Visith Thongboonkerd,Jon B. Klein,William M. Pierce,Rosemarie Booze,William R. Markesbery,D. Allan Butterfield +7 more
TL;DR: The dihydropyrimidinase related protein 2 (DRP‐2), which is involved in the axonal growth and guidance, showed significantly increased level in protein carbonyls in AD brain, suggesting a role for impaired mechanism of neural network formation in AD.
Journal ArticleDOI
Is semantic memory consistently impaired early in the course of alzheimer's disease? neuroanatomical and diagnostic implications
John R. Hodges,Karalyn Patterson +1 more
TL;DR: All patients showed a profound deficit in episodic memory: delayed recall of new verbal and non-verbal material appears to be a particularly sensitive marker of early DAT, in keeping with recent neuropathological studies demonstrating that the transentorhinal region is consistently involved at a very early stage.
References
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A practical method for grading the cognitive state of patients for the clinician
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M. P. Lawton,Elmne M. Brody +1 more
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