Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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Frequency and distribution of Alzheimer's disease in Europe: A collaborative study of 1980–1990 prevalence findings
Walter A. Rocca,Albert Hofman,Carol Brayne,Monique M.B. Breteler,Michael Clarke,John R. M. Copeland,Jean-François Dartigues,Knut Engedal,Olle Hagnell,Thea J. Heeren,Cees Jonker,James Lindesay,Antonio Lobo,Anthony H. Mann,Pekka K. Mölsä,Kevin Morgan,Daniel William O'Connor,Arnaldo da Silva Droux,Raimo Sulkava,David W.K. Kay,Luigi Amaducci +20 more
TL;DR: In this paper, the authors reanalyzed and compared current prevalence estimates of Alzheimer's disease in Europe and found that prevalence increased exponentially with advancing age and, in some populations, was consistently higher in women.
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Fruit and Vegetable Juices and Alzheimer’s Disease: The Kame Project
TL;DR: Fruit and vegetable juices may play an important role in delaying the onset of Alzheimer's disease, particularly among those who are at high risk for the disease.
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Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment.
Jeffrey H. Kordower,Yaping Chu,Glenn T. Stebbins,Steven T. DeKosky,Elizabeth J. Cochran,David A. Bennett,Elliott J. Mufson +6 more
TL;DR: Autopsy data indicate that atrophy and loss of layer II entorhinal cortex neurons occur in elderly subjects with mild cognitive impairment prior to the onset of dementia and suggests that these changes are not exacerbated in early Alzheimer's disease.
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Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050.
TL;DR: The number of people with Alzheimer disease and the proportion of the total population affected will increase substantially and without progress in preventing or delaying onset of Alzheimer disease is expected to increase substantially.
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Simultaneous Measurement of β-Amyloid(1–42), Total Tau, and Phosphorylated Tau (Thr181) in Cerebrospinal Fluid by the xMAP Technology
Annika Olsson,Hugo Vanderstichele,Niels Andreasen,Geert De Meyer,Anders Wallin,Björn Holmberg,Lars Rosengren,Eugeen Vanmechelen,Kaj Blennow +8 more
TL;DR: The clinical study demonstrated that the new multiparametric assay could accurately distinguish patients with AD from patients with other neurologic disorders or control patients, with the diagnostic accuracy reaching recommended consensus criteria for specificity and sensitivity.
References
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“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Studies of illness in the aged. the index of adl: a standardized measure of biological and psychosocial function.
TL;DR: The Index of ADL as discussed by the authors was developed to study results of treatment and prognosis in the elderly and chronically ill. Grades of the Index summarize over-all performance in bathing, dressing, going to toilet, transferring, continence, and feeding.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Journal ArticleDOI
Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.