Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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Detection of Proteins in Normal and Alzheimer's Disease Cerebrospinal Fluid with a Sensitive Sandwich Enzyme‐Linked Immunosorbent Assay
Marc Vandermeeren,Marc Vandermeeren,Marc Mercken,Marc Mercken,Eugeen Vanmechelen,Jan Six,Jan Six,Andre Van De Voorde,Jean-Jacques Martin,Patrick Cras +9 more
TL;DR: CSF levels are significantly increased in Alzheimer's disease and a large group of patients with a diversity of neurological diseases showed overlap with CSF levels in Alzheimer’s disease.
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A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
R. Scott Turner,Ronald G. Thomas,Suzanne Craft,Christopher H. van Dyck,Jacobo Mintzer,Brigid Reynolds,James B. Brewer,Robert A. Rissman,Rema Raman,Paul S. Aisen +9 more
TL;DR: This study provides Class II evidence that for patients with AD resveratrol is safe, well-tolerated, and alters some AD biomarker trajectories.
Reference EntryDOI
Cognitive rehabilitation and cognitive training for early‐stage Alzheimer's disease and vascular dementia
TL;DR: The present findings do not provide strong support for the use of cognitive training interventions for people with early-stage AD or vascular dementia, although they must be viewed with caution due to the limited number of RCTs available and to the methodological limitations identified.
Journal ArticleDOI
Dietary fats and the risk of incident Alzheimer disease.
Martha Clare Morris,Denis A. Evans,Julia L. Bienias,Christine C. Tangney,David A. Bennett,Neelum T. Aggarwal,Julie A. Schneider,Robert S. Wilson +7 more
TL;DR: High intake of unsaturated, unhydrogenated fats may be protective against Alzheimer disease, whereas intake of saturated or trans-unsaturated (hydrogenated) fats may increase risk.
Journal ArticleDOI
The 'preclinical phase' of probable Alzheimer's disease. A 13-year prospective study of the Framingham cohort.
Richard T. Linn,Philip A. Wolf,David Bachman,Janice E. Knoefel,Janet L. Cobb,Albert J. Belanger,Edith Kaplan,Ralph B. D'Agostino +7 more
TL;DR: Findings support previous contentions that a "preclinical phase" of detectable cognitive deficits can precede the clinical diagnosis of probable AD by many years, and support the hypothesis that problems with secondary verbal memory are among the first signs of AD.
References
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“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Studies of illness in the aged. the index of adl: a standardized measure of biological and psychosocial function.
TL;DR: The Index of ADL as discussed by the authors was developed to study results of treatment and prognosis in the elderly and chronically ill. Grades of the Index summarize over-all performance in bathing, dressing, going to toilet, transferring, continence, and feeding.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Journal ArticleDOI
Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.