Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
Reads0
Chats0
TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
Citations
More filters
Journal ArticleDOI
Epidemiology of Alzheimer Disease
Richard Mayeux,Yaakov Stern +1 more
TL;DR: The prevalence and incidence rates, the established environmental risk factors, and the protective factors are discussed, and genetic variants predisposing to disease are reviewed.
Journal ArticleDOI
Education and the prevalence of dementia and Alzheimer's disease
TL;DR: The effect of no or low education on the prevalence of dementia confirms the 1988 prediction of Mortimer2 that education would provide protection against dementia and the recent finding that a close relationship exists between neocortical synaptic density and cognitive decline in AD provides a biological stratum for the postulated “intellectual reserve.”
Journal ArticleDOI
Automatic classification of MR scans in Alzheimer's disease
Stefan Klöppel,Cynthia M. Stonnington,Carlton Chu,Bogdan Draganski,RI Scahill,Jonathan D. Rohrer,Nick C. Fox,Clifford R. Jack,John Ashburner,Richard S. J. Frackowiak +9 more
TL;DR: Assessment of support vector machines assigned individual diagnoses and whether data-sets combined from multiple scanners and different centres could be used to obtain effective classification of scans suggests an important role for computer based diagnostic image analysis for clinical practice.
Journal Article
Geriatric syndromes : Clinical, research, and policy implications of a core geriatric concept. Commentary
TL;DR: In this article, the authors proposed a balanced approach of developing preliminary criteria based on peer-reviewed evidence for defining geriatric syndromes, such as delirium, falls, incontinence, and frailty.
Journal ArticleDOI
Hearing Loss and Incident Dementia
TL;DR: Hearing loss is independently associated with incident all-cause dementia, and whether hearing loss is a marker for early-stage dementia or is actually a modifiable risk factor for dementia deserves further study.
References
More filters
Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Studies of illness in the aged. the index of adl: a standardized measure of biological and psychosocial function.
TL;DR: The Index of ADL as discussed by the authors was developed to study results of treatment and prognosis in the elderly and chronically ill. Grades of the Index summarize over-all performance in bathing, dressing, going to toilet, transferring, continence, and feeding.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Journal ArticleDOI
Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.