Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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Individual differences in rates of change in cognitive abilities of older persons
Robert S. Wilson,Laurel A. Beckett,Lisa L. Barnes,Julie A. Schneider,Julie Bach,Denis A. Evans,David A. Bennett +6 more
TL;DR: The results suggest that change in cognitive function in old age primarily reflects person-specific factors rather than an inevitable developmental process.
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Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics.
TL;DR: The arguments for a causal role for either amyloid deposition or cerebrovascular pathology as the primary trigger in the development of non-genetic AD are summarised.
Journal ArticleDOI
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene
L. Hendriks,Cornelia M. van Duijn,Patrick Cras,Marc Cruts,Wim Van Hul,Frans van Harskamp,Andrew C. Warren,Melvin G. McInnis,Stylianos E. Antonarakis,Jean Jacques Martin,Albert Hofman,Christine Van Broeckhoven +11 more
TL;DR: A novel base mutation in the same exon of the APP gene which co–segregates in one family with presenile dementia and cerebral haemorrhage due to cerebral amyloid angiopathy is reported, suggesting that the clinically distinct entities can be caused by the same mutation.
Journal ArticleDOI
Exercise Plus Behavioral Management in Patients With Alzheimer Disease: A Randomized Controlled Trial
Linda Teri,Laura E. Gibbons,Susan M. McCurry,Rebecca G. Logsdon,David M. Buchner,William E. Barlow,Walter A. Kukull,Andrea Z. LaCroix,Wayne C. McCormick,Eric B. Larson,Eric B. Larson +10 more
TL;DR: Exercise training combined with teaching caregivers behavioral management techniques improved physical health and depression in patients with Alzheimer disease.
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Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease.
Kerryn E. Pike,Gregory Raymond Savage,Victor L. Villemagne,Steven Ng,Simon Moss,Paul Maruff,Chester A. Mathis,William E. Klunk,Colin L. Masters,Christopher C Rowe +9 more
TL;DR: Abeta deposition in the asymptomatic elderly is associated with episodic memory impairment, and this finding, together with the strong relationship between PIB binding and the severity of memory impairment in MCI, suggests that individuals with increased cortical P IB binding are on the path to Alzheimer's disease.
References
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Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
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TL;DR: The Index of ADL as discussed by the authors was developed to study results of treatment and prognosis in the elderly and chronically ill. Grades of the Index summarize over-all performance in bathing, dressing, going to toilet, transferring, continence, and feeding.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
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Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
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