Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
Reads0
Chats0
TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
Citations
More filters
Journal ArticleDOI
Age-specific incidence rates of Alzheimer's disease: the Baltimore Longitudinal Study of Aging.
Claudia H. Kawas,Sarah M. Gray,Sarah M. Gray,Ron Brookmeyer,James L. Fozard,Alan B. Zonderman +5 more
TL;DR: Incidence rates for AD in the Baltimore Longitudinal Study of Aging are consistent with published rates in other studies, and the longitudinally followed subjects of the BLSA offer a unique opportunity to prospectively investigate the antecedents of AD.
Journal ArticleDOI
Plasma Aβ1–40 and Aβ1–42 and the risk of dementia: a prospective case-cohort study
TL;DR: A potential role of plasma Aβ concentrations as a marker of incipient dementia warrants further investigation, and associations were similar for Alzheimer's disease and vascular dementia.
Journal ArticleDOI
A blood based 12-miRNA signature of Alzheimer disease patients
Petra Leidinger,Christina Backes,Stephanie Deutscher,Katja Schmitt,Sabine C. Mueller,Karen S. Frese,Jan Haas,Klemens Ruprecht,Friedemann Paul,Cord F. Stähler,Christoph J. G. Lang,Benjamin Meder,Tamas Bartfai,Eckart Meese,Andreas Keller,Andreas Keller +15 more
TL;DR: The data indicate that deregulated miRNAs in blood might be used as biomarkers in the diagnosis of AD or other neurological diseases.
Journal ArticleDOI
Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease.
TL;DR: It is found that levels of multiple oxidized bases in AD brain specimens were significantly higher in frontal, parietal, and temporal lobes compared to control subjects and that mitochondrial DNA had approximately 10‐fold higher levels of oxidizer bases than nuclear DNA, consistent withHigher levels of oxidative stress in mitochondria.
Journal ArticleDOI
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease
Carlos Cruchaga,Celeste M. Karch,Sheng Chih Jin,Bruno A. Benitez,Y Cai,Rita Guerreiro,Oscar Harari,Joanne Norton,John P. Budde,Sarah Bertelsen,AT Jeng,B Cooper,Tara Skorupa,David Carrell,D Levitch,S Hsu,Jae-Young Choi,Mina Ryten,John Hardy,Daniah Trabzuni,Michael E. Weale,Adaikalavan Ramasamy,Colin Smith,Celeste Sassi,Jose Bras,Gibbs,Dena G. Hernandez,Michelle K. Lupton,John Powell,Paola Forabosco,Perry G. Ridge,Chris Corcoran,JoAnn T. Tschanz,Maria C. Norton,Ronald G. Munger,Cameron Schmutz,M Leary,F. Y. Demirci,Mikhil Bamne,Xingbin Wang,Oscar L. Lopez,Mary Ganguli,Christopher Medway,James Turton,Jenny Lord,Anne Braae,Imelda Barber,Kristelle Brown,Peter Passmore,David Craig,Janet A. Johnston,Bernadette McGuinness,Stephen Todd,R. Heun,Heike Kölsch,Patrick G. Kehoe,Nigel M. Hooper,Emma R.L.C. Vardy,David M. A. Mann,Stuart Pickering-Brown,Noor Kalsheker,James Lowe,Kevin Morgan,David, Smith, A,Gordon K. Wilcock,Donald Warden,Clive Holmes,Pau Pastor,Oswaldo Lorenzo-Betancor,Zoran Brkanac,E Scott,Eric J. Topol,Ekaterina Rogaeva,Andrew B. Singleton,MI Kamboh,St, George-Hyslop, P,Nigel J. Cairns,John C. Morris,John S. K. Kauwe,Alison Goate +79 more
TL;DR: The genetic and functional data indicate that carriers of PLD3 coding variants have a twofold increased risk for LOAD and thatPLD3 influences APP processing, and provides an example of how densely affected families may help to identify rare variants with large effects on risk for disease or other complex traits.
References
More filters
Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Studies of illness in the aged. the index of adl: a standardized measure of biological and psychosocial function.
TL;DR: The Index of ADL as discussed by the authors was developed to study results of treatment and prognosis in the elderly and chronically ill. Grades of the Index summarize over-all performance in bathing, dressing, going to toilet, transferring, continence, and feeding.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Journal ArticleDOI
Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.