Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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Prevalence of Dementia in Older Latinos: The Influence of Type 2 Diabetes Mellitus, Stroke and Genetic Factors
Mary N. Haan,Dan M Mungas,Hector M. González,Teresa A. Ortiz,Ananth Acharya,William J. Jagust +5 more
TL;DR: Dementia prevalence in older Mexican Americans is estimated and the contribution of type 2 diabetes mellitus, stroke, and apolipoprotein E (ApoE) genotype to dementia is evaluated.
Journal ArticleDOI
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs).
Francois Xavier Theillet,Andres Binolfi,Tamara Frembgen-Kesner,Karan S. Hingorani,Mohona Sarkar,Ciara Kyne,Conggang Li,Peter B. Crowley,Lila M. Gierasch,Gary J. Pielak,Adrian H. Elcock,Anne Gershenson,Philipp Selenko +12 more
TL;DR: This work has learned about the unexpected intracellular stability of disordered proteins, their roles in integrating post-translational protein modifications in cell signaling and about their functions in regulatory processes ranging from transcription to cell fate decisions.
Staging Dementia Using Clinical Dementia Rating Scale Sum of Boxes Scores
Sid E. O'Bryant,Stephen C. Waring,C. Munro Cullum,Laura H. Lacritz,Paul J. Massman,Philip J. Lupo,Joan S. Reisch,Rachelle S. Doody +7 more
TL;DR: Owing to the increased range of values, the CDR-SOB score offers several advantages over the global score, including increased utility in tracking changes within and between stages of dementia severity.
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Validity of the Italian Version of the Pittsburgh Sleep Quality Index (PSQI)
Giuseppe Curcio,Daniela Tempesta,Simone Scarlata,Cristina Marzano,Fabio Moroni,Paolo Maria Rossini,Michele Ferrara,Luigi De Gennaro +7 more
TL;DR: Pittsburgh Sleep Quality Index is a useful, valid and reliable tool for the assessment of sleep quality, with an overall efficiency comparable to the mother language version and differentiate “good” from “bad” sleepers.
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Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS)--correlation with simultaneous rCBF-PET measurements.
Christoph Hock,Kersten Villringer,Franz Müller-Spahn,Rüdiger Wenzel,Hauke R. Heekeren,Sigrid Schuh-Hofer,Marc Hofmann,Satoshi Minoshima,Markus Schwaiger,Ulrich Dirnagl,Arno Villringer +10 more
TL;DR: In Alzheimer's disease a marked reduction of regional cerebral blood flow and cerebral hemoglobin oxygenation may occur during activation of brain function, probably mainly in degenerating brain areas, such as the parietal cortex.
References
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A practical method for grading the cognitive state of patients for the clinician
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