Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
Reads0
Chats0
TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
Citations
More filters
Journal ArticleDOI
Vascular risk factors and dementia: How to move forward?
TL;DR: The impact of vascular risk factors on AD and its consequences at the individual level and at the population level are discussed by highlighting the concept of attributable risk.
Journal ArticleDOI
Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease
George Fein,V Di Sclafani,Jody Tanabe,Jody Tanabe,Valerie A. Cardenas,Valerie A. Cardenas,Michael W. Weiner,Michael W. Weiner,William J. Jagust,Bruce R Reed,David Norman,Norbert Schuff,Norbert Schuff,L. Kusdra,T. Greenfield,Helena C. Chui +15 more
TL;DR: Dementia in SIVD, as in AD, correlates best with hippocampal and cortical atrophy, rather than any measure of lacunes, but may be partially indexed by the severity of WMSH.
Journal ArticleDOI
Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study.
Arjen J .C. Slooter,Marc Cruts,Sandra Kalmijn,Albert Hofman,Monique M.B. Breteler,Christine Van Broeckhoven,Cornelia M. van Duijn +6 more
TL;DR: The APOE genotypes explained up to 10% of the variance in age at the onset of dementia and the association between the epsilon4 allele and dementia was strongest in the youngest age category and in those with a family history of dementia.
Journal ArticleDOI
Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance
Michael Ewers,Michael Ewers,Cathal Walsh,John Q. Trojanowski,Leslie M. Shaw,Ronald C. Petersen,Clifford R. Jack,Howard Feldman,Arun L.W. Bokde,Gene E. Alexander,Philip Scheltens,Bruno Vellas,Bruno Dubois,Michael W. Weiner,Michael W. Weiner,Harald Hampel +15 more
TL;DR: Short-term conversion to AD is predicted by single marker models to a comparable degree as by multimarker models in amnestic MCI subjects.
Journal ArticleDOI
Heritability for Alzheimer's Disease: The Study of Dementia in Swedish Twins
Margaret Gatz,Nancy L. Pedersen,Stig Berg,Boo Johansson,Kurt Johansson,James A. Mortimer,Samuel F. Posner,Matti Viitanen,Bengt Winblad,Anders Ahlbom +9 more
TL;DR: Findings indicate a substantial genetic effect for these predominantly late-onset Alzheimer's disease cases, and large intra-pair differences in age of onset suggest that environmental factors are also important in determining whether and when an individual may develop dementia.
References
More filters
Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Studies of illness in the aged. the index of adl: a standardized measure of biological and psychosocial function.
TL;DR: The Index of ADL as discussed by the authors was developed to study results of treatment and prognosis in the elderly and chronically ill. Grades of the Index summarize over-all performance in bathing, dressing, going to toilet, transferring, continence, and feeding.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Journal ArticleDOI
Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.