Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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AD dementia risk in late MCI, in early MCI, and in subjective memory impairment
Frank Jessen,Frank Jessen,Steffen Wolfsgruber,Steffen Wolfsgruber,Birgitt Wiese,Horst Bickel,Edelgard Mösch,Hanna Kaduszkiewicz,Michael Pentzek,Steffi G. Riedel-Heller,Tobias Luck,Angela Fuchs,Siegfried Weyerer,Jochen Werle,Hendrik van den Bussche,Martin Scherer,Wolfgang Maier,Wolfgang Maier,Michael Wagner,Michael Wagner +19 more
TL;DR: To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance, three different approaches are considered.
Journal ArticleDOI
Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer's disease
Vesna Jelic,Sven-Erik Johansson,Ove Almkvist,Masahiro Shigeta,Per Julin,Agneta Nordberg,Bengt Winblad,L-O Wahlund +7 more
TL;DR: A logistic regression model of baseline EEG values adjusted for baseline Mini-Mental Test Examination showed that the important predictors were alpha and theta relative power and mean frequency from left temporo-occipital derivation (T5-O1), which classified 85% of MCI subjects correctly.
Journal ArticleDOI
Association of Low Plasma Aβ42/Aβ40 Ratios With Increased Imminent Risk for Mild Cognitive Impairment and Alzheimer Disease
Neill R. Graff-Radford,Julia E. Crook,John A. Lucas,Bradley F. Boeve,David S. Knopman,Robert J. Ivnik,Glenn E. Smith,Linda H. Younkin,Ronald C. Petersen,Steven G. Younkin +9 more
TL;DR: The plasma Aβ42/Aβ40 ratio may be a useful premorbid biomarker for identifying cognitively normal elderly white subjects who are at increased risk for developing MCI or AD.
A 32-Year Prospective Study of Change in Body Weight and Incident Dementia
Robert Stewart,Kamal Masaki,Qian-Li Xue,Rita Peila,Helen Petrovitch,Lon R. White,Lenore J. Launer +6 more
TL;DR: For example, the authors found that men with incident dementia at the same examination had an additional yearly weight loss of 0.36 kg (95% confidence interval, �0.53 to 0.19).
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Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients
TL;DR: During increased illumination, the stability of the rest-activity rhythm increased in patients with intact vision, but not in visually impaired patients, and the hypothesis than an enduring increase in the daytime environmental illumination level improves rest- activity rhythm disturbances in demented patients is tested.
References
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Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
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Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
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Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.