Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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Dynamics of Gray Matter Loss in Alzheimer's Disease
Paul M. Thompson,Kiralee M. Hayashi,Greig I. de Zubicaray,Andrew L. Janke,Stephen E. Rose,James Semple,David H. Herman,Michael S. Hong,Stephanie S. Dittmer,David M. Doddrell,Arthur W. Toga +10 more
TL;DR: In this article, the authors detected and mapped a dynamically spreading wave of gray matter loss in the brains of patients with Alzheimer's disease (AD) and visualized the loss pattern in four dimensions.
Journal ArticleDOI
Spousal caregivers of dementia victims: longitudinal changes in immunity and health.
TL;DR: Caregivers who reported lower levels of social support at intake and who were most distressed by dementia‐related behaviors showed the greatest and most uniformly negative changes in immune function at follow‐up.
Journal ArticleDOI
Clock drawing in Alzheimer's disease. A novel measure of dementia severity.
Trey Sunderland,James L. Hill,Alan M. Mellow,Brian A. Lawlor,Joshua Gundersheimer,Paul A. Newhouse,Jordan Grafman +6 more
TL;DR: Although the Clock Drawing Test is certainly not a definitive indicator of Alzheimer's disease, the test is easy to administer and provides a useful measure of dementia severity for both research and office settings where sophisticated neuropsychological testing is not available.
Journal ArticleDOI
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Mark H. Tuszynski,Mark H. Tuszynski,Leon J. Thal,Leon J. Thal,Mary Pay,David P. Salmon,Hoi Sang U,Roy A.E. Bakay,Piyush M. Patel,Armin Blesch,H. Lee Vahlsing,H. Lee Vahlsing,Gilbert Ho,Gang Tong,Steven G. Potkin,James H. Fallon,Lawrence A. Hansen,Elliott J. Mufson,Jeffrey H. Kordower,Christine M. Gall,James M. Conner +20 more
TL;DR: A phase 1 trial of ex vivo NGF gene delivery in eight individuals with mild Alzheimer disease, implanting autologous fibroblasts genetically modified to express human NGF into the forebrain found no long-term adverse effects and brain autopsy from one subject suggested robust growth responses to NGF.
Journal ArticleDOI
Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly
Howard J. Aizenstein,Robert D. Nebes,Judith Saxton,Julie C. Price,Chester A. Mathis,Nicholas D. Tsopelas,Scott K. Ziolko,Jeffrey A. James,Beth E. Snitz,Patricia R. Houck,Wenzhu Bi,Ann D. Cohen,Brian J. Lopresti,Steven T. DeKosky,Edythe M. Halligan,William E. Klunk +15 more
TL;DR: In this group of participants without clinically significant impairment, amyloid deposition was not associated with worse cognitive function, suggesting that an elderly person with a significantAmyloid burden can remain cognitively normal, but this finding is based on relatively small numbers and needs to be replicated in larger cohorts.
References
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A practical method for grading the cognitive state of patients for the clinician
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M. P. Lawton,Elmne M. Brody +1 more
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