Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
Citations
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Prevalence of Vitamin D Insufficiency in Patients With Parkinson Disease and Alzheimer Disease
TL;DR: This report of 25(OH)D concentrations in a predominantly white PD cohort demonstrates a significantly higher prevalence of hypovitaminosis in PD vs both healthy controls and patients with AD, supporting a possible role of vitamin D insufficiency in PD.
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Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review.
TL;DR: It is shown that vascular risk factors should be regarded as a major target for preventive measures, but that timing of such measures appears to be critical.
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Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment.
Maja Binnewijzend,Menno M. Schoonheim,Ernesto J. Sanz-Arigita,Alle Meije Wink,Wiesje M. van der Flier,Nelleke Tolboom,Sofie Adriaanse,Jessica S. Damoiseaux,Philip Scheltens,Bart N.M. van Berckel,Frederik Barkhof +10 more
TL;DR: Clinical relevant decreased FC within the default-mode network (DMN) in the precuneus and posterior cingulate cortex compared with controls was observed in Alzheimer's disease.
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Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis.
Emma J. Burton,Robert Barber,Elizabeta B. Mukaetova-Ladinska,J. Robson,Robert H. Perry,Evelyn Jaros,Raj N. Kalaria,John T. O'Brien +7 more
TL;DR: MTA on MRI had robust discriminatory power for distinguishing Alzheimer's disease from DLB and VCI in pathologically confirmed cases and may have utility as a means for stratifying samples in vivo on the basis of putative differences in pathology.
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Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal
Rosebud O. Roberts,David S. Knopman,Michelle M. Mielke,Ruth H. Cha,V. Shane Pankratz,Teresa J.H. Christianson,Yonas E. Geda,Bradley F. Boeve,Robert J. Ivnik,Eric G. Tangalos,Walter A. Rocca,Ronald C. Petersen +11 more
TL;DR: MCI cases, including those who revert to CN, have a high risk of progressing to dementia, suggesting that diagnosis of MCI at any time has prognostic value.
References
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“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Studies of illness in the aged. the index of adl: a standardized measure of biological and psychosocial function.
TL;DR: The Index of ADL as discussed by the authors was developed to study results of treatment and prognosis in the elderly and chronically ill. Grades of the Index summarize over-all performance in bathing, dressing, going to toilet, transferring, continence, and feeding.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Journal ArticleDOI
Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.