Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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Epidemiology and risk factors of dementia.
TL;DR: A brief overview will be given of the epidemiology and risk factors of dementia, and some specific methodological problems associated with studies in dementia are commented on.
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A randomized controlled trial of prednisone in Alzheimer’s disease
Paul S. Aisen,Kenneth L. Davis,J. D. Berg,Kimberly Schafer,Karen Campbell,Ronald G. Thomas,Myron F. Weiner,Martin R. Farlow,Mary Sano,Michael Grundman,Leon J. Thal +10 more
TL;DR: To acquire information about the inflammatory activity of patients with expected dementia transferred to the authors' ward, eosinophilic cationic protein (ECP) in serum was investigated, which is a sensitive marker of inflammatory processes and often used as a marker in clinical studies.
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The release and trans-synaptic transmission of Tau via exosomes
Yipeng Wang,Varun Balaji,Senthilvelrajan Kaniyappan,Lars Krüger,Stephan Irsen,Katharina Tepper,RamReddy Chandupatla,Walter Maetzler,Anja Schneider,Anja Schneider,Eckhard Mandelkow,Eva-Maria Mandelkow +11 more
TL;DR: In this paper, microfluidic devices that allow the culture of cell populations in different compartments were used to investigate the spreading of tau pathology, and they showed that exosomes mediate trans-neuronal transfer of Tau depending on synaptic connectivity.
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Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease
Marc Cruts,Cornelia M. van Duijn,H Backhovens,Marleen Van den Broeck,A. Wehnert,Sally Serneels,R. Sherrington,Mike Hutton,John Hardy,Peter St George-Hyslop,Albert Hofman,Christine Van Broeckhoven +11 more
TL;DR: A systematic mutation analysis of all coding and 5'-non-coding exons of PS -1 and PS -2 in a population-based epidemiological series of 101 unrelated familial and sporadic presenile AD cases found polymorphisms were detected in the promoter and the 5'- non-Coding region of PS-1 and in intronic and exonic sequences of PS -- that will be useful in genetic association studies.
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Flavonoid Intake and Cognitive Decline over a 10-Year Period
Luc Letenneur,Cécile Proust-Lima,A. Le Gouge,Jean-François Dartigues,Pascale Barberger-Gateau +4 more
TL;DR: It is raised the possibility that dietary flavonoid intake is associated with better cognitive evolution, as well as several other potential confounders, after adjustment for age, sex, and educational level.
References
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Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
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TL;DR: The Index of ADL as discussed by the authors was developed to study results of treatment and prognosis in the elderly and chronically ill. Grades of the Index summarize over-all performance in bathing, dressing, going to toilet, transferring, continence, and feeding.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
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Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.