Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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Sex differences in the clinical manifestations of Alzheimer disease pathology.
Lisa L. Barnes,Robert S. Wilson,Julia L. Bienias,Julie A. Schneider,Denis A. Evans,David A. Bennett +5 more
TL;DR: AD pathology is more likely to be clinically expressed as dementia in women than in men, and the relation of global AD pathology to clinical diagnosis differed for men and women.
Journal ArticleDOI
White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study.
David A Medina,Leyla deToledo-Morrell,Fabio L Urresta,John D. E. Gabrieli,John D. E. Gabrieli,Michael E. Moseley,Debra A. Fleischman,David A. Bennett,Sue Leurgans,David A. Turner,Glenn T. Stebbins +10 more
TL;DR: Data demonstrate that white matter changes occur in MCI, prior to the development of dementia, and there was substantial overlap of locations of regional decrease in FA in the MCI and AD groups.
Journal ArticleDOI
Prevalence of Alzheimer's Disease and Dementia in Two Communities: Nigerian Africans and African Americans
Hugh C. Hendrie,Osuntokun Bo,Kathleen S. Hall,Adesola Ogunniyi,Siu L. Hui,F. W. Unverzagt,O. Gureje,C A Rodenberg,O Baiyewu,Beverly Musick +9 more
TL;DR: To the authors' knowledge, this is the first study, using the same research method at the two sites, to report significant differences in rates of dementia and Alzheimer's disease in two different communities with similar ethnic origins.
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Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer’s Disease Treatment Studies
TL;DR: It is indicated that brain metabolism as assessed by FDG PET during mental rest is a sensitive marker of disease progression in Alzheimer's disease over a 1-year period and the feasibility of usingFDG PET as an outcome measure to test the ability of treatments to attenuate the progression of dementia is supported.
Journal ArticleDOI
Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia
Gil D. Rabinovici,William J. Jagust,Ansgar J. Furst,Ansgar J. Furst,Jennifer M. Ogar,Jennifer M. Ogar,Caroline A. Racine,Elizabeth C. Mormino,Elizabeth C. Mormino,James P. O'Neil,Rayhan A. Lal,Nina F. Dronkers,Nina F. Dronkers,Bruce L. Miller,Maria Luisa Gorno-Tempini +14 more
TL;DR: The relationships between language presentation, Aβ amyloidosis, and glucose metabolism in three PPA variants using [11C]‐Pittsburgh compound B and [18F]‐labeled fluorodeoxyglucose positron emission tomography are studied.
References
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Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
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Development of a Rating Scale for Primary Depressive Illness
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M. P. Lawton,Elmne M. Brody +1 more
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