Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease.
TL;DR: It is concluded that education or its covariates or both may provide a reserve that compensates for the neuropathological changes of AD and delays the onset of its clinical manifestations.
Journal ArticleDOI
MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease
Bradford C. Dickerson,I. Goncharova,I. Goncharova,M. P. Sullivan,M. P. Sullivan,C. Forchetti,Robert S. Wilson,David A. Bennett,Laurel A. Beckett,Leyla deToledo-Morrell +9 more
TL;DR: In this paper, the authors compared MRI-derived entorhinal and hippocampal volume in healthy elderly controls, patients who presented at the clinic with cognitive complaints, but did not meet criteria for dementia (non-demented), and patients with very mild AD.
Journal ArticleDOI
Cortical Change in Alzheimer's Disease Detected with a Disease-specific Population-based Brain Atlas
Paul M. Thompson,Michael S. Mega,Roger P. Woods,Chris I. Zoumalan,Chris Lindshield,Rebecca E. Blanton,Jacob Moussai,Colin J. Holmes,Jeffrey L. Cummings,Arthur W. Toga +9 more
TL;DR: 3D mapping of cortical gray matter loss in Alzheimer's disease revealed profiles of structural deficits consistent with the cognitive, metabolic and histological changes in early AD, facilitating longitudinal, genetic and interventional studies of dementia.
Journal ArticleDOI
Alzheimer and Frontotemporal Pathology in Subsets of Primary Progressive Aphasia
M.-Marsel Mesulam,Alissa H. Wicklund,Nancy Johnson,Emily Rogalski,Gabriel C. Léger,Alfred Rademaker,Sandra Weintraub,Eileen H. Bigio +7 more
TL;DR: To identify predictors of Alzheimer's disease (AD) versus frontotemporal lobar degeneration pathology in primary progressive aphasia (PPA), and determine whether the AD pathology is atypically distributed to fit the aphasic phenotype.
Journal ArticleDOI
Neuroanatomical correlates of behavioural disorders in dementia
Howard J. Rosen,S. C. Allison,Guido F. Schauer,Maria Luisa Gorno-Tempini,Michael W. Weiner,Bruce L. Miller +5 more
TL;DR: The findings underscore the utility of studying patients with dementia for understanding the neuroanatomical basis of social and emotional functions and highlight the importance of distinct regions on the medial wall of the right frontal lobe in regulating different behaviours.
References
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“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Studies of illness in the aged. the index of adl: a standardized measure of biological and psychosocial function.
TL;DR: The Index of ADL as discussed by the authors was developed to study results of treatment and prognosis in the elderly and chronically ill. Grades of the Index summarize over-all performance in bathing, dressing, going to toilet, transferring, continence, and feeding.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Journal ArticleDOI
Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.