Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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Quantitative and qualitative analyses of clock drawings in Alzheimer's and Huntington's disease.
Isabelle Rouleau,David P. Salmon,Nelson Butters,Nelson Butters,Colleen Kennedy,Colleen Kennedy,Katheryn McGuire,Katheryn McGuire +7 more
TL;DR: While both DAT and HD patients have significant visuoconstructive difficulties even in the early stages of their disorders, the specific cognitive processes underlying their quantitative impairments are quite different.
Journal ArticleDOI
Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging
Stephen E. Rose,Fang Chen,Jonathan B. Chalk,Fernando Zelaya,Wendy Strugnell,Mark Benson,James Semple,David M. Doddrell +7 more
TL;DR: Patients with probable Alzheimer's disease showed a highly significant reduction in the integrity of the association white matter fibre tracts, such as the splenium of the corpus callosum, superior longitudinal fasciculus, and cingulum, compared with normal controls.
Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer Disease
Robert C. Green,Lon S. Schneider,David A. Amato,Andrew P. Beelen,Gordon K. Wilcock,Edward Swabb,Kenton Zavitz +6 more
TL;DR: Tarenflurbil had no beneficial effect on the co-primary outcomes (difference in change from baseline to month 18 vs placebo, based on least squares means: 0.1; P =.86 and -0.5 for ADCS-ADL; 95% CI, -1.9 to 0.9;P =.48) using an intent-to-treat analysis as discussed by the authors.
Journal ArticleDOI
Preclinical prediction of Alzheimer's disease using SPECT
Keith A. Johnson,Kenneth J. Jones,Kenneth J. Jones,B. L. Holman,John A. Becker,P. A. Spiers,Andrew Satlin,Marilyn S. Albert +7 more
TL;DR: Three of the four brain regions important for discriminating Converters from normal controls involve a distributed brain network pertaining to memory, suggesting that this network may be selectively affected in the earliest stages of AD.
Journal ArticleDOI
Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults
Mark A. Reger,Mark A. Reger,G. Stennis Watson,G. Stennis Watson,Pattie S. Green,Pattie S. Green,Laura D. Baker,Laura D. Baker,Brenna Cholerton,Brenna Cholerton,Mark A. Fishel,Mark A. Fishel,Stephen R. Plymate,Stephen R. Plymate,Monique M. Cherrier,Gerard D. Schellenberg,William H. Frey,Suzanne Craft,Suzanne Craft +18 more
TL;DR: The findings suggest that groups with different genetic risks for AD may show differential dose-response curves following intranasal insulin administration, and whether the effects of insulin differ between participants with and without the APOE- epsilon4 allele.
References
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A practical method for grading the cognitive state of patients for the clinician
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