Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.Abstract:
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information become available.read more
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The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part VI. Family history assessment: A multicenter study of first-degree relatives of Alzheimer's disease probands and nondemented spouse controls
Jeremy M. Silverman,K. Raiford,Steven D. Edland,Gerda G. Fillenbaum,John C. Morris,C. Clark,Walter A. Kukull,Albert Heyman +7 more
TL;DR: This is the first reported multicenter family-history study of AD, and it supports earlier reports of familial factors in AD and indicates a higher risk to female relatives of AD probands.
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Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease
Lutz Frölich,D. Blum-Degen,Hans-Gert Bernstein,S. Engelsberger,J. Humrich,S. Laufer,D. Muschner,A. Thalheimer,A. Türk,Siegfried Hoyer,R. Zöchling,Karl W. Boissl,Kurt A. Jellinger,Peter Riederer +13 more
TL;DR: It is shown for the first time that insulin and c-peptide concentration in the brain are correlated and decrease with aging, as do brain insulin receptor densities, which favor the hypothesis that insulin dependent functions may be of pathogenetic relevance in sporadic Alzheimer's disease.
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Altered functional connectivity in early Alzheimer's disease: A resting‐state fMRI study
TL;DR: The results supported previous studies that have reported an anterior–posterior disconnection phenomenon and increased within‐lobe functional connectivity in AD patients and suggest that AD may disturb the correlation/anti‐correlation effect in the two intrinsically anti‐correlated networks.
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The Relationships Between Age, Sex, and the Incidence of Dementia and Alzheimer Disease: A Meta-analysis
TL;DR: In this article, the authors found that the acceleration of incidence rates for AD and dementia slows down with the increase in age, although there is no sign of a decline in the incidence rates themselves.
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Effectiveness of Cholinesterase Inhibitors and Memantine for Treating Dementia: Evidence Review for a Clinical Practice Guideline
Parminder Raina,Pasqualina Santaguida,Afisi S. Ismaila,Christopher Patterson,David Cowan,Mitchell Levine,Lynda Booker,Mark Oremus +7 more
TL;DR: This systematic review systematically evaluates the evidence for the effectiveness of these 5 drugs in improving outcomes in cognition, global function, behavior, and quality of life among patients with dementia.
References
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“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Studies of illness in the aged. the index of adl: a standardized measure of biological and psychosocial function.
TL;DR: The Index of ADL as discussed by the authors was developed to study results of treatment and prognosis in the elderly and chronically ill. Grades of the Index summarize over-all performance in bathing, dressing, going to toilet, transferring, continence, and feeding.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Journal ArticleDOI
Assessment of older people: self-maintaining and instrumental activities of daily living
M. P. Lawton,Elmne M. Brody +1 more
TL;DR: Two scales first standardized on their own population are presented, one of which taps a level of functioning heretofore inadequately represented in attempts to assess everyday functional competence, and the other taps a schema of competence into which these behaviors fit.