Efficacy of single and repeated administration of ketamine in unipolar and bipolar depression: a meta-analysis of randomized clinical trials
Joanna Kryst,Paweł Kawalec,Paweł Kawalec,Alicja Mikrut Mitoraj,Andrzej Pilc,Andrzej Pilc,Władysław Lasoń,Tomasz Brzostek +7 more
Reads0
Chats0
TLDR
It is shown for the first time that repeated ketamine administration is effective in sustaining initial antidepressant effects observed after single dosing, in patients with treatment-resistant depression.About:
This article is published in Pharmacological Reports.The article was published on 2020-04-16 and is currently open access. It has received 57 citations till now. The article focuses on the topics: Randomized controlled trial & Ketamine.read more
Citations
More filters
Journal ArticleDOI
The efficacy of psychotherapies and pharmacotherapies for mental disorders in adults: an umbrella review and meta‐analytic evaluation of recent meta‐analyses
TL;DR: After more than half a century of research, thousands of RCTs and millions of invested funds, the effect sizes of psychotherapy and pharmacotherapies for mental disorders are limited, suggesting a ceiling effect for treatment research as presently conducted.
Journal ArticleDOI
Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine.
Wei Yao,Qianqian Cao,Shilin Luo,Lujuan He,Chun Yang,Chun Yang,Jiaxu Chen,Qi Qi,Kenji Hashimoto,Ji-chun Zhang +9 more
TL;DR: In this article, the authors identified nuclear receptor-binding protein 1 (NRBP1) that could contribute to different antidepressant-like effects of the two enantiomers in chronic social defeat stress (CSDS) model.
Journal ArticleDOI
Integrating psychotherapy and psychopharmacology: psychedelic-assisted psychotherapy and other combined treatments
TL;DR: The therapeutic mechanisms behind both conventional and psychedelic paradigms, including the evolution of this knowledge and the associated explanatory frameworks are reviewed, and how psychedelics have provided insights about psychiatric illnesses and treatments over the past decades are explored.
Journal ArticleDOI
Ketamine and the Future of Rapid-Acting Antidepressants.
TL;DR: The history of antidepressant treatment advances that preceded the ketamine discovery are reviewed, mechanistic hypotheses for how ketamine may exert its antidepressant effects are critically examined, and the impact this knowledge has had on ongoing drug discovery efforts are discussed.
Journal ArticleDOI
Depression: Biological markers and treatment.
Gordana Nedic Erjavec,Marina Šagud,Matea Nikolac Perkovic,Dubravka Svob Strac,Marcela Konjevod,Lucija Tudor,Sandra Uzun,Nela Pivac +7 more
TL;DR: An overview of the role of major stress response system, the HPA axis, and its dysregulation in depression, possible involvement of neurotrophins, especially brain-derived neurotrophic factor, glial cell line- derived neurotrophicfactor and insulin-like growth factor-1 are provided.
References
More filters
Journal ArticleDOI
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
TL;DR: Moher et al. as mentioned in this paper introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses, which is used in this paper.
Journal ArticleDOI
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
TL;DR: A structured summary is provided including, as applicable, background, objectives, data sources, study eligibility criteria, participants, interventions, study appraisal and synthesis methods, results, limitations, conclusions and implications of key findings.
Journal ArticleDOI
Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Theo Vos,Amanuel Alemu Abajobir,Kalkidan Hassen Abate,Cristiana Abbafati,Kaja Abbas,Foad Abd-Allah,Rizwan Suliankatchi Abdulkader,Abdishakur M. Abdulle,Teshome Abuka Abebo,Semaw Ferede Abera,Semaw Ferede Abera,Victor Aboyans,Laith J. Abu-Raddad,Ilana N. Ackerman,Abdu A. Adamu,Olatunji O. Adetokunboh,Mohsen Afarideh,Ashkan Afshin,Sanjay K. Agarwal,Rakesh Aggarwal,Anurag Agrawal,Anurag Agrawal,Sutapa Agrawal,Hamid Ahmadieh,Muktar Beshir Ahmed,Miloud Taki Eddine Aichour,Amani Nidhal Aichour,Ibtihel Aichour,Sneha Aiyar,Rufus Akinyemi,Rufus Akinyemi,Nadia Akseer,Faris Lami,Fares Alahdab,Ziyad Al-Aly,Khurshid Alam,Khurshid Alam,Noore Alam,Tahiya Alam,Deena Alasfoor,Kefyalew Addis Alene,Raghib Ali,Reza Alizadeh-Navaei,Ala'a Alkerwi,François Alla,Peter Allebeck,Christine Allen,Fatma Al-Maskari,Rajaa Al-Raddadi,Ubai Alsharif,Shirina Alsowaidi,Khalid A Altirkawi,Azmeraw T. Amare,Azmeraw T. Amare,Erfan Amini,Walid Ammar,Yaw Ampem Amoako,Hjalte H Andersen,Carl Abelardo T. Antonio,Palwasha Anwari,Johan Ärnlöv,Al Artaman,Krishna Kumar Aryal,Hamid Asayesh,Solomon Weldegebreal Asgedom,Reza Assadi,Tesfay Mehari Atey,Niguse Tadele Atnafu,Sachin R Atre,Leticia Avila-Burgos,Euripide Frinel G Arthur Avokphako,Ashish Awasthi,Umar Bacha,Alaa Badawi,Kalpana Balakrishnan,Amitava Banerjee,Marlena S Bannick,Aleksandra Barac,Ryan M Barber,Suzanne Barker-Collo,Till Bärnighausen,Simón Barquera,Lars Barregard,Lope H Barrero,Sanjay Basu,Bob Battista,Katherine E Battle,Bernhard T. Baune,Shahrzad Bazargan-Hejazi,Shahrzad Bazargan-Hejazi,Justin Beardsley,Neeraj Bedi,Neeraj Bedi,Ettore Beghi,Yannick Béjot,Bayu Begashaw Bekele,Michelle L. Bell,Derrick A Bennett,Isabela M. Benseñor,Jennifer Benson,Adugnaw Berhane,Derbew Fikadu Berhe,Eduardo Bernabé,Balem Demtsu Betsu,Mircea Beuran,Addisu Shunu Beyene,Neeraj Bhala,Anil Bhansali,Samir Bhatt,Zulfiqar A Bhutta,Zulfiqar A Bhutta,Sibhatu Biadgilign,Burcu Kucuk Bicer,Kelly Bienhoff,Boris Bikbov,Charles Birungi,Stan Biryukov,Donal Bisanzio,Donal Bisanzio,Habtamu Mellie Bizuayehu,Dube Jara Boneya,Dube Jara Boneya,Soufiane Boufous,Rupert R A Bourne,Alexandra Brazinova,Traolach S. Brugha,Rachelle Buchbinder,Lemma Negesa Bulto Bulto,Blair R. Bumgarner,Zahid A Butt,Lucero Cahuana-Hurtado,Ewan Cameron,Mate Car,Hélène Carabin,Hélène Carabin,Jonathan R. Carapetis,Rosario Cárdenas,David O Carpenter,Juan Jesus Carrero,Austin Carter,Félix Carvalho,Daniel C Casey,Valeria Caso,Carlos A Castañeda-Orjuela,Chris D Castle,Ferrán Catalá-López,Hsing-Yi Chang,Jung-Chen Chang,Fiona J Charlson,Honglei Chen,Mirriam Chibalabala,Chioma Ezinne Chibueze,Vesper Hichilombwe Chisumpa,Abdulaal A Chitheer,Devasahayam J. Christopher,Liliana G Ciobanu,Massimo Cirillo,Danny Colombara,Cyrus Cooper,Paolo Cortesi,Michael H. Criqui,John A. Crump,Abel Fekadu Dadi,Koustuv Dalal,Lalit Dandona,Lalit Dandona,Rakhi Dandona,Rakhi Dandona,José Neves,Dragos Virgil Davitoiu,Barbora de Courten,Diego De Leo,Barthelemy Kuate Defo,Louisa Degenhardt,Louisa Degenhardt,Selina Deiparine,Robert P. Dellavalle,Robert P. Dellavalle,Kebede Deribe,Don C. Des Jarlais,Subhojit Dey,Samath D Dharmaratne,Samath D Dharmaratne,Preet Kaur Dhillon,Daniel Dicker,Eric L. Ding,Shirin Djalalinia,Huyen Phuc Do,E. Ray Dorsey,Kadine Priscila Bender dos Santos,Dirk Douwes-Schultz,Kerrie E. Doyle,Tim Driscoll,Manisha Dubey,Bruce Bartholow Duncan,Ziad El-Khatib,Jerisha Ellerstrand,Ahmad Ali Enayati,Aman Yesuf Endries,Sergey Petrovich Ermakov,Holly E. Erskine,Babak Eshrati,Sharareh Eskandarieh,Alireza Esteghamati,Kara Estep,Fanuel Belayneh Bekele Fanuel,Carla Sofia e Sa Farinha,André Faro,Farshad Farzadfar,Mir Sohail Fazeli,Valery L. Feigin,Valery L. Feigin,Seyed-Mohammad Fereshtehnejad,Seyed-Mohammad Fereshtehnejad,João C. Fernandes,Alize J. Ferrari,Tesfaye Regassa Feyissa,Irina Filip,Florian Fischer,Christina Fitzmaurice,Abraham D Flaxman,Luisa Sorio Flor,Nataliya Foigt,Kyle J Foreman,Richard C. Franklin,Nancy Fullman,Thomas Fürst,João M. Furtado,Neal D. Futran,Emmanuela Gakidou,Morsaleh Ganji,Alberto L Garcia-Basteiro,Teshome Gebre,Teshome Gebre,Tsegaye Tewelde Gebrehiwot,Ayele Geleto,Ayele Geleto,Bikila Lencha Gemechu,Hailay Abrha Gesesew,Peter W. Gething,Alireza Ghajar,Katherine B Gibney,Paramjit Gill,Richard F. Gillum,Richard F. Gillum,Ibrahim Abdelmageem Mohamed Ginawi,Ababi Zergaw Giref,Melkamu Dedefo Gishu,Giorgia Giussani,William W Godwin,Audra L Gold,Ellen M Goldberg,Philimon Gona,Amador Goodridge,Sameer Vali Gopalani,Atsushi Goto,Alessandra C. Goulart,Max Griswold,Harish Chander Gugnani,Rashmi Gupta,Rajeev Gupta,Tanush Gupta,Vipin Gupta,Nima Hafezi-Nejad,Gessessew Bugssa Hailu,Alemayehu Hailu,Randah R. Hamadeh,Samer Hamidi,Alexis J Handal,Graeme J. Hankey,Graeme J. Hankey,Sarah Wulf Hanson,Yuantao Hao,Hilda L Harb,Habtamu Abera Hareri,Josep Maria Haro,James D. Harvey,Mohammad Sadegh Hassanvand,Rasmus Havmoeller,Caitlin Hawley,Simon I. Hay,Roderick J. Hay,Nathaniel J Henry,Ileana Heredia-Pi,Julio C. Montañez Hernandez,Pouria Heydarpour,Hans W. Hoek,Howard J. Hoffman,Nobuyuki Horita,H. Dean Hosgood,Sorin Hostiuc,Peter J. Hotez,Damian G Hoy,Aung Soe Htet,Guoqing Hu,Hsiang Huang,Chantal Huynh,Kim Moesgaard Iburg,Ehimario U. Igumbor,Chad Ikeda,Caleb Mackay Salpeter Irvine,Kathryn H. Jacobsen,Nader Jahanmehr,Mihajlo Jakovljevic,Simerjot K Jassal,Mehdi Javanbakht,Sudha P Jayaraman,Panniyammakal Jeemon,Paul N. Jensen,Vivekanand Jha,Vivekanand Jha,Guohong Jiang,Denny John,Sarah Charlotte Johnson,Catherine O. Johnson,Jost B. Jonas,Mikk Jürisson,Zubair Kabir,Rajendra Kadel,Amaha Kahsay,Ritul Kamal,Haidong Kan,Nadim E. Karam,André Karch,Corine Karema,Amir Kasaeian,Getachew Mullu Kassa,Nigussie Assefa Kassaw,Nicholas J Kassebaum,Anshul Kastor,Srinivasa Vittal Katikireddi,Anil Kaul,Norito Kawakami,Peter Njenga Keiyoro,Andre Pascal Kengne,Andre Keren,Yousef Khader,Ibrahim A Khalil,Ejaz Ahmad Khan,Young-Ho Khang,Ardeshir Khosravi,Jagdish Khubchandani,Aliasghar Ahmad Kiadaliri,Christian Kieling,Yun Jin Kim,Daniel Kim,Pauline Kim,Ruth W Kimokoti,Yohannes Kinfu,Adnan Kisa,Adnan Kisa,Katarzyna Kissimova-Skarbek,Mika Kivimäki,Ann Kristin Knudsen,Yoshihiro Kokubo,Dhaval Kolte,Jacek A Kopec,Soewarta Kosen,Parvaiz A Koul,Ai Koyanagi,Michael Kravchenko,Sanjay Krishnaswami,Kristopher J Krohn,G Anil Kumar,Pushpendra Kumar,Sanjiv Kumar,Hmwe H Kyu,Dharmesh Kumar Lal,Ratilal Lalloo,Nkurunziza Lambert,Qing Lan,Anders Larsson,Pablo M Lavados,Janet L Leasher,Paul H. Lee,Jong-Tae Lee,James Leigh,Cheru Tesema Leshargie,Janni Leung,Ricky Leung,Miriam Levi,Yichong Li,Yongmei Li,Darya Li Kappe,Xiaofeng Liang,Misgan Legesse Liben,Stephen S Lim,Shai Linn,Patrick Y Liu,Angela Liu,Shiwei Liu,Yang Liu,Rakesh Lodha,Giancarlo Logroscino,Stephanie J. London,Katharine J Looker,Alan D. Lopez,Alan D. Lopez,Stefan Lorkowski,Paulo A. Lotufo,Nicola Low,Rafael Lozano,Tim C.D. Lucas,Erlyn Rachelle King Macarayan,Hassan Magdy Abd El Razek,Mohammed Magdy Abd El Razek,Mahdi Mahdavi,Marek Majdan,Reza Majdzadeh,Azeem Majeed,Reza Malekzadeh,Reza Malekzadeh,Rajesh Malhotra,Deborah Carvalho Malta,Abdullah Al Mamun,Helena Manguerra,Treh Manhertz,Ana Mantilla,Lorenzo G. Mantovani,Chabila C Mapoma,Laurie B. Marczak,Jose Martinez-Raga,Francisco Rogerlândio Martins-Melo,Ira Martopullo,Winfried März,Manu Raj Mathur,Mohsen Mazidi,Colm McAlinden,Madeline McGaughey,John J. McGrath,John J. McGrath,Martin McKee,Claire McNellan,Suresh Mehata,Man Mohan Mehndiratta,Tefera Chane Mekonnen,Peter Memiah,Ziad A. Memish,Walter Mendoza,Mubarek Abera Mengistie,Desalegn Tadese Mengistu,George A. Mensah,Tuomo J. Meretoja,Atte Meretoja,Haftay Berhane Mezgebe,Renata Micha,Anoushka Millear,Ted R. Miller,Ted R. Miller,Edward J Mills,Mojde Mirarefin,Erkin M. Mirrakhimov,Awoke Misganaw,Shiva Raj Mishra,Philip B. Mitchell,Karzan Abdulmuhsin Mohammad,Alireza Mohammadi,Kedir Endris Mohammed,Shafiu Mohammed,Sanjay K. Mohanty,Ali H. Mokdad,Sarah K Mollenkopf,Lorenzo Monasta,Marcella Montico,Maziar Moradi-Lakeh,Paula Moraga,Rintaro Mori,Chloe Morozoff,Shane D. Morrison,Mark Moses,Cliff Mountjoy-Venning,Kalayu Birhane Mruts,Ulrich O Mueller,Kate Muller,M. E. Murdoch,Gudlavalleti V S Murthy,Kamarul Imran Musa,Jean B. Nachega,Gabriele Nagel,Mohsen Naghavi,Aliya Naheed,Kovin Naidoo,Luigi Naldi,Vinay Nangia,Gopalakrishnan Natarajan,Dumessa Edessa Negasa,Ruxandra Irina Negoi,Ionut Negoi,Charles R. Newton,Charles R. Newton,Josephine W. Ngunjiri,Trang Huyen Nguyen,Quyen Nguyen,Cuong Tat Nguyen,Grant Nguyen,Minh Nguyen,Emma Nichols,Dina Nur Anggraini Ningrum,Dina Nur Anggraini Ningrum,Sandra Nolte,Vuong Minh Nong,Bo Norrving,Jean Jacques Noubiap,Martin O'Donnell,Felix Akpojene Ogbo,In-Hwan Oh,Anselm Okoro,Olanrewaju Oladimeji,Olanrewaju Oladimeji,Tinuke O Olagunju,Andrew T Olagunju,Andrew T Olagunju,Helen E Olsen,Bolajoko O. Olusanya,Jacob Olusegun Olusanya,Kanyin Ong,John Nelson Opio,Eyal Oren,Eyal Oren,Alberto Ortiz,Aaron Osgood-Zimmerman,Majdi Osman,Mayowa O. Owolabi,Mahesh Pa,Rosana E. Pacella,Adrian Pana,Basant Kumar Panda,Christina Papachristou,Christina Papachristou,Eun-Kee Park,Charles D. H. Parry,Mahboubeh Parsaeian,Scott B. Patten,George C Patton,Katherine R. Paulson,Neil Pearce,David M. Pereira,David M. Pereira,Norberto Perico,Konrad Pesudovs,Carrie Beth Peterson,Max Petzold,Michael R. Phillips,David M. Pigott,Julian David Pillay,Christine Pinho,Dietrich Plass,Martin A Pletcher,Svetlana Popova,Richie Poulton,Farshad Pourmalek,Dorairaj Prabhakaran,Noela M Prasad,Narayan Prasad,Carrie Purcell,Mostafa Qorbani,Reginald Quansah,Beatriz Paulina Ayala Quintanilla,Rynaz H S Rabiee,Amir Radfar,Anwar Rafay,Kazem Rahimi,Afarin Rahimi-Movaghar,Vafa Rahimi-Movaghar,Mohammad Hifz Ur Rahman,Mahfuzar Rahman,Rajesh Kumar Rai,Sasa Rajsic,Usha Ram,Chhabi Lal Ranabhat,Zane Rankin,Puja C Rao,P. V. Rao,Salman Rawaf,Sarah E Ray,Robert C. Reiner,Nikolas Reinig,Marissa B Reitsma,Giuseppe Remuzzi,Andre M. N. Renzaho,Serge Resnikoff,Satar Rezaei,Antonio Luiz Pinho Ribeiro,Luca Ronfani,Gholamreza Roshandel,Gholamreza Roshandel,Gregory A. Roth,Ambuj Roy,Enrico Rubagotti,George Mugambage Ruhago,Soheil Saadat,Nafis Sadat,Mahdi Safdarian,Sare Safi,Saeid Safiri,Rajesh Sagar,Ramesh Sahathevan,Joseph Salama,Huda Omer Ba Saleem,Joshua A. Salomon,Sundeep Salvi,Abdallah M. Samy,Juan Sanabria,Juan Sanabria,Damian Santomauro,Itamar S. Santos,João Vasco Santos,Milena M Santric Milicevic,Benn Sartorius,Maheswar Satpathy,Monika Sawhney,Sonia Saxena,Maria Inês Schmidt,Ione Jayce Ceola Schneider,Ben Schöttker,David C. Schwebel,Falk Schwendicke,Soraya Seedat,Sadaf G. Sepanlou,Sadaf G. Sepanlou,Edson Serván-Mori,Tesfaye Setegn,Katya Anne Shackelford,Amira Shaheen,Masood Ali Shaikh,Mansour Shamsipour,Sheikh Mohammed Shariful Islam,Sheikh Mohammed Shariful Islam,Jayendra Sharma,Rajesh Sharma,Jun She,Peilin Shi,Chloe Shields,Girma Temam Shifa,Mika Shigematsu,Yukito Shinohara,Rahman Shiri,Reza Shirkoohi,Shreya Shirude,Kawkab Shishani,Mark G. Shrime,Abla M. Sibai,Inga Dora Sigfusdottir,Inga Dora Sigfusdottir,Diego Augusto Santos Silva,João Pedro Silva,Dayane Gabriele Alves Silveira,Jasvinder A. Singh,Narinder Pal Singh,Dhirendra N Sinha,Eirini Skiadaresi,Vegard Skirbekk,Erica Leigh Slepak,Amber Sligar,David L. Smith,Mari Smith,Badr Hasan Sobaih,Eugene Sobngwi,Reed J D Sorensen,Tatiane Cristina Moraes Sousa,Luciano A. Sposato,Chandrashekhar T Sreeramareddy,Vinay Srinivasan,Jeffrey D. Stanaway,Vasiliki Stathopoulou,Nicholas Steel,Murray B. Stein,Dan J. Stein,Dan J. Stein,Timothy J. Steiner,Timothy J. Steiner,Caitlyn Steiner,S. Steinke,S. Steinke,Mark A. Stokes,Lars Jacob Stovner,Bryan Strub,Michelle L Subart,Mu'awiyyah Babale Sufiyan,Bruno F. Sunguya,Bruno F. Sunguya,Patrick J Sur,Patrick J Sur,Soumya Swaminathan,Bryan L. Sykes,Dillon O Sylte,Rafael Tabarés-Seisdedos,Getachew Redae Taffere,Jukka Takala,Nikhil Tandon,Mohammad Tavakkoli,Nuno Taveira,Hugh R. Taylor,Arash Tehrani-Banihashemi,Tesfalidet Tekelab,Abdullah Sulieman Terkawi,Dawit Jember Tesfaye,Belay Tesssema,Ornwipa Thamsuwan,Katie E Thomas,Amanda G. Thrift,Tenaw Yimer Tiruye,Ruoyan Tobe-Gai,Mette Christophersen Tollånes,Mette Christophersen Tollånes,Marcello Tonelli,Roman Topor-Madry,Roman Topor-Madry,Miguel Tortajada,Mathilde Touvier,Bach Xuan Tran,Suryakant Tripathi,Christopher Troeger,Thomas Truelsen,Derrick Tsoi,Kald Beshir Tuem,Emin Murat Tuzcu,Stefanos Tyrovolas,Kingsley N. Ukwaja,Eduardo A. Undurraga,Eduardo A. Undurraga,Chigozie Jesse Uneke,Rachel L Updike,Olalekan A. Uthman,Benjamin S Chudi Uzochukwu,Job F M van Boven,Santosh Varughese,Tommi Vasankari,S Venkatesh,Narayanaswamy Venketasubramanian,Ramesh Vidavalur,Francesco Saverio Violante,Sergey K Vladimirov,Vasiliy Victorovich Vlassov,Stein Emil Vollset,Fiseha Wadilo,Tolassa Wakayo,Tolassa Wakayo,Yuan-Pang Wang,Marcia R. Weaver,Scott Weichenthal,Elisabete Weiderpass,Robert G. Weintraub,Andrea Werdecker,Ronny Westerman,Harvey Whiteford,Harvey Whiteford,Tissa Wijeratne,Charles Shey Wiysonge,Charles D.A. Wolfe,Charles D.A. Wolfe,Rachel Woodbrook,Anthony D. Woolf,Abdulhalik Workicho,Denis Xavier,Gelin Xu,Simon Yadgir,Mohsen Yaghoubi,Bereket Yakob,Lijing L Yan,Yuichiro Yano,Pengpeng Ye,Hassen Hamid Yimam,Paul S. F. Yip,Naohiro Yonemoto,Seok Jun Yoon,Marcel Yotebieng,Mustafa Z. Younis,Mustafa Z. Younis,Zoubida Zaidi,Maysaa El Sayed Zaki,Elias Asfaw Zegeye,Zerihun Menlkalew Zenebe,Xueying Zhang,Maigeng Zhou,Ben Zipkin,Sanjay Zodpey,Liesl Zühlke,Christopher J L Murray +778 more
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016.
Journal ArticleDOI
Global, regional, and national incidence, prevalence, andyears lived with disability for 354 diseases and injuries for195 countries and territories, 1990–2017: a systematicanalysis for the Global Burden of Disease Study 2017
Gbd Disease,Injury Incidence,Lorenzo Monasta,Luca Ronfani,Ettore Beghi,Giorgia Giussani,Boris Bikbov,Norberto Perico,Cristina Bosetti,Monica Cortinovis,Silvano Gallus,Giuseppe Remuzzi +11 more
TL;DR: All-cause age-standardised YLD rates decreased by 3·9% from 1990 to 2017; however, the all-age YLD rate increased by 7·2% while the total sum of global YLDs increased from 562 million (421–723) to 853 million (642–1100).