FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:Â
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
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MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID, and Fragile X syndrome.
TL;DR: A class of small non-coding RNAs known as microRNAs (miRNAs) involvement in ID development and progression with special focus on Down syndrome (DS) and X-linked ID (XLID) [including Fragile X syndrome (FXS)].
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FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype.
Jason Arsenault,Shervin Gholizadeh,Yosuke Niibori,Laura K. K. Pacey,Sebok Kumar Halder,Enea Koxhioni,Ayumu Konno,Hirokazu Hirai,David R. Hampson +8 more
TL;DR: A wide range of neuronal F MRP transgene levels was achieved in individual mice after intra-cerebroventricular administration of adeno-associated viral vectors coding for FMRP.
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Fragile X Mental Retardation Protein Requirements in Activity-Dependent Critical Period Neural Circuit Refinement
TL;DR: It is concluded that FMRP is absolutely required for experience-dependent changes in synaptic connectivity during the developmental critical period of neural circuit optimization for sensory input.
Journal ArticleDOI
De novo Mutations (DNMs) in Autism Spectrum Disorder (ASD): Pathway and Network Analysis.
TL;DR: Different aspects of the DNMs associated with ASD are reviewed, including their functional annotation and classification, and the main bioinformatics tools commonly employed to study these are outlined.
Journal ArticleDOI
Multielectrode array analysis of EEG biomarkers in a mouse model of Fragile X Syndrome.
TL;DR: In this article, a 30-channel mouse multielectrode array (MEA) system was used to record and analyze resting and stimulus-evoked EEG signals in WT vs. Fmr1 KO mice.
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