FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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RNA Protein Interaction in Neurons
TL;DR: What is known about RNA binding proteins in neurons is reviewed and the potential biologic and neurologic significance of neuronal RNA regulatory systems is explored.
Journal ArticleDOI
Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions
TL;DR: In this article, the authors describe distinct mechanisms by which the homeostasis of RNA binding proteins is compromised in neurological disorders through their reduced expression level, increased propensity to aggregate or sequestration by abnormal RNAs.
Journal ArticleDOI
Transmission, Development, and Plasticity of Synapses
TL;DR: Techniques for studying synapses in Drosophila are discussed, with a focus on the larval neuromuscular junction (NMJ), a well-established model glutamatergic synapse.
Journal ArticleDOI
Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder
TL;DR: Findings support a role for miRNA dysregulation in ASD pathophysiology and provide a rich data set and framework for future analyses of miRNAs in neuropsychiatric diseases.
Journal ArticleDOI
Monosomes actively translate synaptic mRNAs in neuronal processes
Anne Biever,Caspar Glock,Georgi Tushev,Elena Ciirdaeva,Tamas Dalmay,Julian David Langer,Erin M. Schuman +6 more
TL;DR: How a diverse set of neuronal proteins might be synthesized from a limited population of polysomes present in small synaptic volumes is investigated and direct evidence for the preferential translation of a high number of both pre and postsynaptic transcripts by monosomes is provided.
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