FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
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Synaptic NMDA receptor-mediated currents in anterior piriform cortex are reduced in the adult fragile X mouse
James Gocel,John Larson +1 more
TL;DR: Low NMDA receptor signaling may help to explain the LTP deficit seen at APC ASSN synapses in Fmr1-KO mice at 6-18months of age, but does not explain normal LTP at thesesynapses in mice 3-6months old.
Journal ArticleDOI
The translational regulator FMRP controls lipid and glucose metabolism in mice and humans.
Antoine Leboucher,Didier F. Pisani,Laura Martinez-Gili,Julien Chilloux,Patricia Bermudez-Martin,Anke Van Dijck,Tariq Ganief,Boris Macek,Jérôme A.J. Becker,Julie Le Merrer,R. Frank Kooy,Ez-Zoubir Amri,Edouard W. Khandjian,Marc-Emmanuel Dumas,Laetitia Davidovic +14 more
TL;DR: This study unravels metabolic phenotypes in FXS and further supports the importance of translational regulation in the homeostatic control of systemic metabolism.
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Synaptic control of mRNA translation by reversible assembly of XRN1 bodies
Luciana Luchelli,Luciana Luchelli,María Gabriela Thomas,Graciela Lidia Boccaccio,Graciela Lidia Boccaccio +4 more
TL;DR: A role for the SX‐bodies in the reversible masking and silencing of mRNAs at the synapse is supported, and XRN1 knockdown impairs the translational repression triggered by NMDA.
Journal ArticleDOI
Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA.
Ruben Soto-Acosta,Xuping Xie,Chao Shan,Coleman Baker,Pei Yong Shi,Shannan L. Rossi,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco,Shelton S. Bradrick +8 more
TL;DR: This work identified fragile X mental retardation protein (FMRP) as a ZIKV sfRNA-binding protein and confirmed this interaction in cultured cells and mouse testes, indicating that FMRP is a ZikV restriction factor that is antagonized by the sf RNA.
Journal ArticleDOI
Influence of the fragile X mental retardation (FMR1) gene on the brain and working memory in men with normal FMR1 alleles.
Jun Yi Wang,David R Hessl,Christine Iwahashi,Katherine Cheung,Andrea Schneider,Randi J Hagerman,Paul J. Hagerman,Susan M. Rivera +7 more
TL;DR: The findings suggest that the FMR1 gene is a genetic factor common for both working memory and brain structure, and has implications for the understanding of the transmission of intelligence andbrain structure.
References
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