FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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Novel West syndrome candidate genes in a Chinese cohort.
Jing Peng,Ying Wang,Fang He,Chen Chen,Liwen Wu,Lifen Yang,Yu-Ping Ma,Wen Zhang,Zi‐Qing Shi,Chao Chen,Kun Xia,Hui Guo,Fei Yin,Nan Pang +13 more
TL;DR: This study was designed to uncover new candidate genes for West syndrome, a classic form of early infantile epileptic encephalopathy characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on electroencephalography.
Journal ArticleDOI
Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila
Seung Kyu Lee,Yutong Xue,Weiping Shen,Yongqing Zhang,Yuyoung Joo,Muzammil Ahmad,Madoka Chinen,Yi Ding,Wai Lim Ku,Supriyo De,Elin Lehrmann,Kevin G. Becker,Elissa P. Lei,Keji Zhao,Sige Zou,Alexei A. Sharov,Weidong Wang +16 more
TL;DR: Evidence is provided that in Drosophila, Topoisomerase 3β interacts biochemically and genetically with the RNAi-induced silencing complex (RISC) to promote heterochromatin formation and transcriptional silencing.
Journal ArticleDOI
From FMRP function to potential therapies for fragile X syndrome.
TL;DR: This review focuses on the current understanding of FMRP function and potential therapeutic strategies that are mainly based on the manipulation of F MRP targets and knowledge gained from FXS pathophysiology.
Journal ArticleDOI
The contribution of [1H] magnetic resonance spectroscopy to the study of excitation-inhibition in autism.
Laura Ajram,Andreia Carvalho Pereira,Alice M. S. Durieux,Hester E. Velthius,Marija M. Petrinovic,Grainne M. McAlonan +5 more
TL;DR: Findings from magnetic resonance spectroscopy add to the evidence that differences in the brain's excitatory glutamate and inhibitory &ggr;‐aminobutyric acid (GABA) balance may be both a key biomarker and a tractable treatment target in ASD.
Journal ArticleDOI
Unraveling the Pathways to Neuronal Homeostasis and Disease: Mechanistic Insights into the Role of RNA-Binding Proteins and Associated Factors
TL;DR: This review discusses the roles of Pumilio, Staufen, IGF2BP, FMRP, Sam68, CPEB, NOVA, ELAVL, SMN, TDP43, FUS, TAF15, and TIA1/TIAR in RNA metabolism by analyzing their specific molecular and cellular function, the neurological symptoms associated with their perturbation, and their axodendritic transport/localization.
References
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Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
Biometery: The principles and practice of statistics in biological research
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Book
Biometry: The Principles and Practice of Statistics in Biological Research
Robert R. Sokal,F. James Rohlf +1 more
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Journal ArticleDOI
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
TL;DR: The hierarchical model of Lonnstedt and Speed (2002) is developed into a practical approach for general microarray experiments with arbitrary numbers of treatments and RNA samples and the moderated t-statistic is shown to follow a t-distribution with augmented degrees of freedom.
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