FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
Jennifer C. Darnell,Sarah J. Van Driesche,Chaolin Zhang,Ka Ying Sharon Hung,Aldo Mele,Claire E. Fraser,Elizabeth F. Stone,Cynthia Chen,John J. Fak,Sung Wook Chi,Donny D. Licatalosi,Joel D. Richter,Robert B. Darnell,Robert B. Darnell +13 more
TLDR
A brain polyribosome-programmed translation system is developed, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs and suggests multiple targets for clinical intervention in FXS and ASD.About:
This article is published in Cell.The article was published on 2011-07-22 and is currently open access. It has received 1861 citations till now. The article focuses on the topics: FMR1 & RNA-binding protein.read more
Citations
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Outcome measures for clinical trials in fragile X syndrome.
Elizabeth Berry-Kravis,David R Hessl,Leonard J Abbeduto,Allan L. Reiss,Andrea Beckel-Mitchener,Tiina K. Urv +5 more
TL;DR: Recommendations for optimal outcome measures in cognitive, behavioral, and biomarker/medical domains are presented to guide the selection of measures in clinical trials and lead to the use of a more consistent battery of measures across trials.
Journal ArticleDOI
The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex
Perry W.E. Spratt,Roy Ben-Shalom,Caroline M. Keeshen,Kenneth J. Burke,Rebecca L. Clarkson,Stephen Sanders,Kevin J. Bender +6 more
TL;DR: It is shown that NaV1.2 is unexpectedly critical for dendritic excitability and synaptic function in mature pyramidal neurons in addition to regulating early developmental axonal excitability in ASD.
Journal ArticleDOI
Specificity factors in cytoplasmic polyadenylation.
TL;DR: This review aims to introduce cytoplasmic polyadenylation with an emphasis on the factors and elements mediating this process for different mRNAs and in different animal species.
Journal ArticleDOI
Low load for disruptive mutations in autism genes and their biased transmission
Ivan Iossifov,Dan Levy,Jeremy Allen,Kenny Ye,Michael Ronemus,Yoon-ha Lee,Boris Yamrom,Michael Wigler +7 more
TL;DR: Gene targets of de novo mutation in autistic children have a lighter load of rare disruptive variation than typical human genes, which suggests such mutations are under negative selection and autism genes are highly vulnerable to mutation.
Journal ArticleDOI
Transactivation of programmed ribosomal frameshifting by a viral protein.
Yanhua Li,Emmely E. Treffers,Sawsan Napthine,Ali Tas,Longchao Zhu,Zhi Sun,Susanne Bell,Brian L. Mark,Peter A. van Veelen,Martijn J. van Hemert,Andrew E. Firth,Ian Brierley,Eric J. Snijder,Ying Fang,Ying Fang +14 more
TL;DR: It is demonstrated for the first time, to the authors' knowledge, that a protein can function as a transactivator of ribosomal frameshifted, and the newly identified frameshifting determinants provide potential antiviral targets for arterivirus disease control and prevention.
References
More filters
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
Biometery: The principles and practice of statistics in biological research
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Book
Biometry: The Principles and Practice of Statistics in Biological Research
Robert R. Sokal,F. James Rohlf +1 more
TL;DR: In this paper, the authors present a model for the analysis of variance in a single-classification and two-way and multiway analysis of Variance with the assumption of correlation.
Journal ArticleDOI
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
TL;DR: The hierarchical model of Lonnstedt and Speed (2002) is developed into a practical approach for general microarray experiments with arbitrary numbers of treatments and RNA samples and the moderated t-statistic is shown to follow a t-distribution with augmented degrees of freedom.
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